Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   EL264_RS04775 Genome accession   NZ_LR134519
Coordinates   991921..993705 (+) Length   594 a.a.
NCBI ID   WP_126474460.1    Uniprot ID   -
Organism   Helicobacter pylori strain NCTC12823     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 986921..998705
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL264_RS04745 (NCTC12823_00945) motB 987687..988460 (+) 774 WP_126474458.1 flagellar motor protein MotB -
  EL264_RS04750 (NCTC12823_00946) - 988457..988903 (+) 447 WP_001081239.1 hypothetical protein -
  EL264_RS04755 (NCTC12823_00947) - 988972..990633 (+) 1662 WP_126474859.1 ABC transporter permease/substrate-binding protein -
  EL264_RS04760 (NCTC12823_00948) - 990635..991276 (+) 642 WP_126474459.1 ATP-binding cassette domain-containing protein -
  EL264_RS04765 - 991288..991467 (-) 180 WP_001876614.1 hypothetical protein -
  EL264_RS04770 (NCTC12823_00949) - 991459..991920 (+) 462 WP_000437177.1 hypothetical protein -
  EL264_RS04775 (NCTC12823_00950) uvrC 991921..993705 (+) 1785 WP_126474460.1 excinuclease ABC subunit UvrC Machinery gene
  EL264_RS04780 (NCTC12823_00951) - 993716..994981 (+) 1266 WP_108583905.1 homoserine dehydrogenase -
  EL264_RS04785 (NCTC12823_00952) - 994982..995326 (+) 345 WP_126474461.1 YraN family protein -
  EL264_RS04790 (NCTC12823_00953) trxA 995415..995735 (+) 321 WP_000020199.1 thioredoxin -
  EL264_RS04795 (NCTC12823_00954) trxB 995740..996675 (+) 936 WP_126474462.1 thioredoxin-disulfide reductase -
  EL264_RS04800 (NCTC12823_00955) - 997032..997853 (+) 822 WP_126474463.1 glycosyltransferase family 25 protein -
  EL264_RS04805 (NCTC12823_00956) - 998071..998319 (-) 249 WP_000790555.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68595.87 Da        Isoelectric Point: 9.7128

>NTDB_id=1123788 EL264_RS04775 WP_126474460.1 991921..993705(+) (uvrC) [Helicobacter pylori strain NCTC12823]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLS
ACSNEALKELQDFISHQYSKKVALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHSSSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=1123788 EL264_RS04775 WP_126474460.1 991921..993705(+) (uvrC) [Helicobacter pylori strain NCTC12823]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCCATCCGTAATAATGAAATCACGCCCA
ACCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAATGAGCAA
GACGCTTTGATTTTAGAAAACTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTATATGGATTTTTCTACCGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGCAATTTGCGTTTTGAAGAAGCCCTAATTTACAGAGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAGGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATACCAGAACAAATTTTATTGAGC
GCTTGCTCTAATGAAGCGCTTAAGGAATTGCAAGATTTTATCTCCCACCAATACTCTAAAAAAGTCGCTCTTAGCATTCC
TAAAAAAGGCGACAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAGGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCTAGCAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCCTTCCAAAAAAACTCTTATCGGCG
CTACCATTTGAAAGGCTCTAACGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGTTCTAAAGGGGGCGCTAAAGATATTAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

98.316

100

0.983

Multiple sequence alignment