Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   EL256_RS04860 Genome accession   NZ_LR134517
Coordinates   1022171..1023955 (+) Length   594 a.a.
NCBI ID   WP_126442935.1    Uniprot ID   -
Organism   Helicobacter pylori strain NCTC13345     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1017171..1028955
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL256_RS04830 (NCTC13345_00956) motB 1017936..1018709 (+) 774 WP_001085358.1 flagellar motor protein MotB -
  EL256_RS04835 (NCTC13345_00957) - 1018706..1019152 (+) 447 WP_001081239.1 hypothetical protein -
  EL256_RS04840 (NCTC13345_00958) - 1019221..1020882 (+) 1662 WP_126442933.1 ABC transporter permease/substrate-binding protein -
  EL256_RS04845 (NCTC13345_00959) - 1020885..1021526 (+) 642 WP_000659397.1 ATP-binding cassette domain-containing protein -
  EL256_RS04850 (NCTC13345_00960) - 1021538..1021717 (-) 180 WP_000468793.1 hypothetical protein -
  EL256_RS04855 (NCTC13345_00961) - 1021709..1022170 (+) 462 WP_097687839.1 hypothetical protein -
  EL256_RS04860 (NCTC13345_00962) uvrC 1022171..1023955 (+) 1785 WP_126442935.1 excinuclease ABC subunit UvrC Machinery gene
  EL256_RS04865 (NCTC13345_00963) - 1023966..1025231 (+) 1266 WP_126442936.1 homoserine dehydrogenase -
  EL256_RS04870 (NCTC13345_00964) - 1025232..1025576 (+) 345 WP_001211699.1 YraN family protein -
  EL256_RS04875 (NCTC13345_00965) trxA 1025663..1025983 (+) 321 WP_000020206.1 thioredoxin -
  EL256_RS04880 (NCTC13345_00966) trxB 1025989..1026924 (+) 936 WP_126442938.1 thioredoxin-disulfide reductase -
  EL256_RS04885 (NCTC13345_00967) - 1027294..1028115 (+) 822 WP_126442940.1 glycosyltransferase family 25 protein -
  EL256_RS04890 (NCTC13345_00968) - 1028334..1028582 (-) 249 WP_000790555.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68638.81 Da        Isoelectric Point: 9.6734

>NTDB_id=1123757 EL256_RS04860 WP_126442935.1 1022171..1023955(+) (uvrC) [Helicobacter pylori strain NCTC13345]
MADLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNPRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNETLKELQEFISHQYSKKIVLNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDWILEEARSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRHYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=1123757 EL256_RS04860 WP_126442935.1 1022171..1023955(+) (uvrC) [Helicobacter pylori strain NCTC13345]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTGTCCGCAATAATGAAATCACGCCCA
ATCCTCGCGCAAGCTTGCGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTGATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAACCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAGTTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACTAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTAATTTATAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCGCAAGCAACAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAAGCGATGAAGCAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATCTTATTGAGC
GCTTGTTCTAATGAAACGCTTAAAGAATTGCAAGAGTTTATCTCTCACCAATATTCTAAAAAAATCGTTCTTAATATCCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATTGGATTTTAGAAGAAGCGCGATCGCTCTTTAATTTAGAGTGCGTGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCCTTCCAAAAAAACTCTTATCGGCA
CTACCATCTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAATTGCTCACTAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATTTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

UvrB/uvrC motif (UVR)

(205-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.138

100

0.971

Multiple sequence alignment