Detailed information NTG1121278

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EL136_RS06270
• Genome accession: NZ_LR134317
• Coordinates: 1316505..1317542 (-)
• Length: 345 a.a.
• NCBI ID: WP_014622492.1
• Uniprot ID: A0A6D2LSH8
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC6180
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1311505..1322542

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL136_RS06245 (NCTC6180_01287)	-	1311795..1312028 (-)	234	WP_012515231.1	YqgQ family protein	-
EL136_RS06250 (NCTC6180_01288)	-	1312398..1312928 (-)	531	WP_012515230.1	Dps family protein	-
EL136_RS06255 (NCTC6180_01289)	-	1313280..1313777 (+)	498	WP_231144810.1	peptidase	-
EL136_RS06260 (NCTC6180_01290)	rlmN	1314204..1315286 (-)	1083	WP_154804046.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EL136_RS06265 (NCTC6180_01291)	-	1315290..1315904 (-)	615	WP_012679162.1	YutD family protein	-
EL136_RS06270 (NCTC6180_01292)	sepM	1316505..1317542 (-)	1038	WP_014622492.1	SepM family pheromone-processing serine protease	Regulator
EL136_RS06275 (NCTC6180_01293)	coaD	1317520..1318020 (-)	501	WP_154804047.1	pantetheine-phosphate adenylyltransferase	-
EL136_RS06280 (NCTC6180_01294)	rsmD	1318010..1318549 (-)	540	WP_012515220.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EL136_RS06285 (NCTC6180_01295)	asnA	1318719..1319711 (-)	993	WP_154804048.1	aspartate--ammonia ligase	-
EL136_RS06290 (NCTC6180_01296)	arcC	1319931..1320881 (-)	951	WP_154804049.1	carbamate kinase	-
EL136_RS06295 (NCTC6180_01297)	-	1320899..1322230 (-)	1332	WP_043983725.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37450.05 Da
• Isoelectric Point: 9.2833

>NTDB_id=1121278 EL136_RS06270 WP_014622492.1 1316505..1317542(-) (sepM) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
MKTIKKFKWWLIGFVALLFLLLTLFFPLPYYIEMPGGAYDIRSVLTVNGKEDKEKGAYQFVVVSLSRATLAKLLYAWLTP
FTEISTMEDTTGGYSDADYLRINRFYMETSQNSAVYQALTLAGKEVSFDYKGVYVLDVSKDSSFKGVLHLADTVTGVNGK
TFTTSADLIDYVSHLTLGDEVQVQFTTAGESKTEKGKIIKLKNGKNGIGITLTDHTQVISGDEVDFSTGGVGGPSAGLMF
TLDIYDQINHEDLRKGRVIAGTGTIGKDGKVGDIGGAGLKVAAAAAAGADIFFVPNNPVDKDVKKANPKAISNYEEAKKA
AKRLKTAMKIIPVKTVQDAISYLKK

Nucleotide

• Length: 1038 bp

>NTDB_id=1121278 EL136_RS06270 WP_014622492.1 1316505..1317542(-) (sepM) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
ATGAAAACAATAAAAAAATTTAAATGGTGGCTGATTGGCTTTGTTGCCTTGCTTTTTCTACTGTTGACACTGTTTTTCCC
CTTGCCTTATTATATTGAAATGCCAGGTGGAGCCTATGATATTCGCTCGGTATTGACTGTCAATGGCAAAGAGGATAAGG
AAAAGGGAGCTTATCAGTTTGTTGTAGTGAGCCTCAGTCGGGCCACCTTGGCTAAATTGCTCTATGCTTGGCTAACGCCT
TTCACTGAGATTAGCACCATGGAAGATACTACTGGTGGCTATAGCGATGCTGACTACCTGCGAATTAATCGCTTTTATAT
GGAAACCTCTCAAAACAGCGCTGTTTATCAGGCCCTTACTCTAGCAGGCAAGGAGGTAAGCTTTGATTATAAGGGTGTTT
ATGTCTTAGACGTCAGCAAGGATTCTAGCTTTAAAGGTGTGCTGCACCTAGCAGATACAGTGACAGGTGTCAATGGTAAA
ACATTTACAACGTCTGCCGATCTGATTGATTATGTTTCTCATTTGACCTTGGGAGATGAGGTGCAGGTACAATTTACAAC
CGCTGGTGAGTCAAAGACTGAAAAAGGAAAGATTATTAAGCTTAAAAACGGTAAAAATGGGATTGGCATTACCCTGACAG
ACCACACACAGGTCATTTCTGGTGATGAGGTCGACTTTAGCACCGGAGGTGTGGGTGGACCAAGTGCAGGCTTGATGTTT
ACTCTTGATATTTATGATCAAATCAATCACGAAGACTTGCGCAAGGGACGTGTGATTGCTGGTACAGGAACCATTGGCAA
GGATGGAAAAGTTGGAGATATTGGCGGGGCGGGCCTAAAGGTGGCTGCCGCCGCCGCTGCTGGTGCTGATATTTTCTTTG
TTCCAAATAATCCTGTGGATAAGGACGTCAAAAAAGCAAATCCTAAGGCTATTAGCAATTACGAGGAGGCTAAAAAAGCA
GCTAAACGACTAAAGACAGCAATGAAAATTATTCCTGTGAAAACCGTTCAAGATGCTATAAGCTACCTTAAAAAATAG

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-311)

3D structure

• AlphaFold DB: A0A6D2LSH8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	70.145	100	0.701