Detailed information NTG1121232

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EL139_RS06730
• Genome accession: NZ_LR134316
• Coordinates: 1325925..1326962 (+)
• Length: 345 a.a.
• NCBI ID: WP_111717149.1
• Uniprot ID: A0A380JVE1
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1320925..1331962

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL139_RS06710 (NCTC6181_01368)	arcC	1322457..1323407 (+)	951	WP_111717153.1	carbamate kinase	-
EL139_RS06715 (NCTC6181_01369)	asnA	1323733..1324725 (+)	993	WP_003061055.1	aspartate--ammonia ligase	-
EL139_RS06720 (NCTC6181_01370)	rsmD	1324918..1325457 (+)	540	WP_111717939.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EL139_RS06725 (NCTC6181_01371)	coaD	1325447..1325938 (+)	492	WP_111717151.1	pantetheine-phosphate adenylyltransferase	-
EL139_RS06730 (NCTC6181_01372)	sepM	1325925..1326962 (+)	1038	WP_111717149.1	SepM family pheromone-processing serine protease	Regulator
EL139_RS06735 (NCTC6181_01373)	-	1327243..1328226 (+)	984	WP_003051900.1	LacI family DNA-binding transcriptional regulator	-
EL139_RS06740 (NCTC6181_01374)	rbsK	1328219..1329130 (+)	912	WP_111717147.1	ribokinase	-
EL139_RS06745 (NCTC6181_01375)	rbsD	1329105..1329503 (+)	399	WP_111717144.1	D-ribose pyranase	-
EL139_RS06750 (NCTC6181_01376)	-	1329519..1330997 (+)	1479	WP_111717142.1	sugar ABC transporter ATP-binding protein	-
EL139_RS06755 (NCTC6181_01377)	rbsC	1330999..1331940 (+)	942	WP_111717140.1	ribose ABC transporter permease	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37544.11 Da
• Isoelectric Point: 9.5393

>NTDB_id=1121232 EL139_RS06730 WP_111717149.1 1325925..1326962(+) (sepM) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
MKTIKKIKWWLISLIALVALLIVLFFPLPYYVEMPGGAYDIRSVVKVNGKEDKDKGSYQFVAVSLSRASLAQLLYAWLTP
FTEISSVEDTTGGYSDADYIRINQFYMETSQNAAVYQALTLADKPVTLDYKGVYVLDVSKDSTFKGALNLADTVTGVNHK
QFTSSTELVDYVSHLKLGDKVTVQFISNSEPKSETGRIIKLKNGKNGIGIALTDHTKVNSADKIEFSTQGVGGPSAGLMF
TLDIYDQINKEDLRKGRHIAGTGTIGKNGEVGDIGGAGLKVVAAADAGAEIFFVPNNPVDKAVKKANPKAISNYEEAKRA
AKQLKTKMKIVPVTTVQDALAYLRQ

Nucleotide

• Length: 1038 bp

>NTDB_id=1121232 EL139_RS06730 WP_111717149.1 1325925..1326962(+) (sepM) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181]
ATGAAAACAATTAAAAAAATTAAATGGTGGCTGATTAGCCTAATTGCCCTCGTGGCTCTGCTTATCGTCCTCTTTTTCCC
TCTTCCTTACTATGTTGAAATGCCTGGCGGAGCCTATGACATTCGATCTGTGGTCAAGGTTAATGGCAAAGAAGATAAAG
ATAAAGGCTCCTATCAGTTTGTGGCAGTCAGTCTCAGTCGAGCCAGTTTAGCTCAATTGCTCTATGCTTGGCTAACCCCT
TTTACTGAAATCAGTTCAGTTGAGGACACCACAGGCGGTTACAGCGATGCAGACTATATCCGCATTAATCAATTCTACAT
GGAAACCTCACAAAATGCTGCGGTCTATCAGGCATTGACCTTGGCAGACAAACCAGTTACTTTGGACTACAAAGGGGTCT
ATGTGTTAGATGTTAGCAAGGATTCAACCTTTAAAGGTGCTTTAAACTTAGCAGATACGGTAACGGGAGTGAATCACAAA
CAATTTACGAGTTCAACAGAACTTGTGGACTATGTCTCTCATTTAAAACTTGGTGATAAGGTGACTGTGCAGTTTATTAG
TAATAGCGAACCTAAGTCTGAAACAGGTCGTATCATCAAACTAAAAAATGGTAAAAATGGTATCGGCATTGCTTTAACAG
ACCATACTAAAGTCAATTCAGCAGACAAAATCGAGTTTAGTACCCAAGGTGTTGGGGGTCCTAGCGCAGGCTTAATGTTT
ACACTAGATATCTACGACCAAATTAATAAAGAAGACCTTCGTAAAGGAAGACATATCGCCGGGACAGGAACCATTGGTAA
AAATGGTGAAGTTGGAGATATTGGCGGTGCGGGTCTTAAGGTCGTTGCTGCTGCAGATGCTGGTGCTGAGATTTTCTTTG
TGCCGAATAATCCTGTGGATAAAGCTGTTAAAAAAGCCAATCCAAAAGCTATTAGCAATTATGAAGAGGCCAAGCGAGCA
GCCAAGCAGTTAAAAACAAAAATGAAAATTGTTCCTGTAACAACTGTTCAGGATGCCCTAGCCTACCTTCGTCAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-192)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-299)

3D structure

• AlphaFold DB: A0A380JVE1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	71.884	100	0.719