Detailed information NTG1121123

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EL107_RS03235
• Genome accession: NZ_LR134314
• Coordinates: 648534..649571 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8302
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 643534..654571

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL107_RS03215 (NCTC8302_00647)	-	644283..644909 (+)	627	WP_011184760.1	prepilin peptidase	-
EL107_RS03220 (NCTC8302_00648)	rlmN	644991..646070 (-)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EL107_RS03225 (NCTC8302_00649)	-	646074..646694 (-)	621	WP_002992791.1	YutD family protein	-
EL107_RS03230 (NCTC8302_00650)	-	647142..648118 (-)	977	Protein_635	LacI family DNA-binding transcriptional regulator	-
EL107_RS03235 (NCTC8302_00652)	sepM	648534..649571 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
EL107_RS03240 (NCTC8302_00653)	coaD	649558..650049 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
EL107_RS03245 (NCTC8302_00654)	rsmD	650039..650578 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EL107_RS03250 (NCTC8302_00655)	asnA	650701..651693 (-)	993	WP_011184764.1	aspartate--ammonia ligase	-
EL107_RS03255 (NCTC8302_00656)	arcC	652006..652956 (-)	951	WP_011018011.1	carbamate kinase	-
EL107_RS03260 (NCTC8302_00657)	-	652976..654307 (-)	1332	WP_011184765.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1121123 EL107_RS03235 WP_010922499.1 648534..649571(-) (sepM) [Streptococcus pyogenes strain NCTC8302]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1121123 EL107_RS03235 WP_010922499.1 648534..649571(-) (sepM) [Streptococcus pyogenes strain NCTC8302]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693