Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   EL115_RS06690 Genome accession   NZ_LR134307
Coordinates   1351108..1353387 (+) Length   759 a.a.
NCBI ID   WP_126441584.1    Uniprot ID   -
Organism   Streptococcus milleri strain NCTC10708     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1346108..1358387
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL115_RS06665 (NCTC10708_01328) - 1347034..1347576 (-) 543 WP_003036027.1 ClbS/DfsB family four-helix bundle protein -
  EL115_RS06670 (NCTC10708_01329) - 1347708..1347845 (-) 138 WP_003071957.1 FeoB-associated Cys-rich membrane protein -
  EL115_RS06675 (NCTC10708_01330) feoB 1347854..1349998 (-) 2145 WP_126441580.1 ferrous iron transport protein B -
  EL115_RS06680 (NCTC10708_01331) - 1349995..1350471 (-) 477 WP_003068195.1 FeoA family protein -
  EL115_RS06685 (NCTC10708_01332) - 1350639..1350869 (-) 231 WP_126441582.1 DUF1797 family protein -
  EL115_RS06690 (NCTC10708_01333) clpE 1351108..1353387 (+) 2280 WP_126441584.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  EL115_RS06695 (NCTC10708_01334) - 1353434..1354039 (-) 606 WP_126441585.1 GyrI-like domain-containing protein -
  EL115_RS06700 (NCTC10708_01335) - 1354099..1354992 (-) 894 WP_126441587.1 helix-turn-helix transcriptional regulator -
  EL115_RS06705 (NCTC10708_01336) - 1355149..1355598 (+) 450 WP_126441589.1 NUDIX hydrolase -
  EL115_RS06710 (NCTC10708_01337) - 1355663..1355962 (+) 300 WP_003068181.1 DUF1827 family protein -
  EL115_RS09970 - 1356448..1356645 (-) 198 WP_420031122.1 hypothetical protein -
  EL115_RS06720 (NCTC10708_01338) - 1357185..1357730 (-) 546 WP_126441591.1 tRNA (mnm(5)s(2)U34)-methyltransferase -

Sequence

Protein


Download         Length: 759 a.a.        Molecular weight: 84727.92 Da        Isoelectric Point: 4.9533

>NTDB_id=1120896 EL115_RS06690 WP_126441584.1 1351108..1353387(+) (clpE) [Streptococcus milleri strain NCTC10708]
MLCQNCKINESTIHLYTNVNGKQHQVDLCQNCYQIMKTDPNNALFRGMTNMNNQNNLDPFDDFFSNLGNFQNHQEPQTPP
TQSGGGYGNGGYGSNQGGSTRQQVPQQPKGLLEEFGINVTEFARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEPG
VGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRSRQDVILFIDEIHEIVGAGAAG
DGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDDAI
EAAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLVEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQ
QNKMADQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLISLADDLKAHVIGQDDAVDKIAKAIRRNRVGLGTPDRPIG
SFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILLDEI
EKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEANVGFGAAREGRTNSVIGELGDFFSPEFMNRFD
GIIEFKSLSKENLLQIVDLMLEDVNKRLAVNGIHLDVTDKVKEKLVNLGYDPKMGARPLRRTIQDHIEDAITDYYLEHPS
EKELKAVMTSNSKIVIKSSKKSENETEKEIKTTADDTAN

Nucleotide


Download         Length: 2280 bp        

>NTDB_id=1120896 EL115_RS06690 WP_126441584.1 1351108..1353387(+) (clpE) [Streptococcus milleri strain NCTC10708]
ATGCTTTGTCAAAATTGTAAAATAAACGAATCAACTATTCACCTTTACACAAATGTGAATGGAAAACAACACCAAGTTGA
CCTCTGTCAAAATTGTTATCAAATCATGAAAACAGACCCAAATAATGCCTTATTTCGTGGCATGACCAATATGAACAATC
AAAATAATTTAGACCCTTTTGATGATTTCTTTAGCAATCTAGGGAATTTTCAAAATCATCAAGAACCGCAGACCCCTCCT
ACTCAATCAGGTGGCGGATACGGTAACGGAGGCTATGGTTCCAATCAAGGTGGCAGCACGCGCCAACAAGTACCACAACA
ACCCAAAGGCCTCCTAGAAGAATTTGGTATCAATGTAACTGAATTTGCTCGGCGGGGCGAGATTGACCCTGTAATTGGTC
GTGACGAAGAAATTGTGCGCGTCATTGAAATCCTCAATCGTAGAACGAAGAACAATCCTGTCCTCATCGGAGAGCCCGGT
GTCGGTAAAACAGCAGTTGTCGAAGGCTTGGCTCAGAAAATTGTAGACGGTGATGTGCCACATAAACTCCAAGGCAAAGA
AGTCATTCGTTTAGATGTCGTTAGTTTGGTTCAAGGAACTGGTATCCGTGGTCAATTTGAAGAACGAATGCAAAAACTCA
TGGAGGAAATCCGTTCTCGTCAGGATGTGATTCTATTCATTGATGAAATCCATGAAATCGTTGGAGCTGGTGCAGCTGGA
GATGGGAATATGGATGCTGGTAACATCTTAAAACCTGCTCTTGCTCGCGGCGAGCTTCAATTAGTTGGTGCCACAACTCT
CAATGAGTATCGCATTATCGAAAAAGATGCAGCACTGGAACGCCGGATGCAGCCAGTAAAAGTGGATGAACCAACGGTTG
AAGAAACCATTACTATTCTAAAAGGCATTCAAAAAAAATACGAAGACTATCATCACGTTAAATACACAGATGATGCTATT
GAAGCGGCGGCTGTCTTGTCCAATCGTTATATCCAAGATCGCTTCTTGCCCGATAAGGCCATTGACTTGCTAGACGAAGC
AGGCTCTAAGATGAATCTGACACTTAACTTTGTCGATCCAAAAGTCATTGATCAACGATTGGTAGAAGCTGAAAACCTCA
AGGCACAAGCTACTCGTGATGAAGATTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCCAAATACAAAGAAATGCAG
CAAAATAAAATGGCAGACCAAGATACGCCTATCATCAGTGAAAAAACCATTGAGCATATCATTGAGCAAAAGACAAATAT
CCCAGTTGGCGACTTAAAAGAAAAGGAACAATCACAACTGATTAGTCTGGCTGATGATTTGAAGGCACATGTCATCGGTC
AAGATGATGCCGTTGATAAAATTGCAAAGGCCATTCGCCGTAATCGAGTTGGACTAGGTACACCAGACCGACCAATTGGT
TCTTTCCTTTTTGTTGGGCCAACCGGTGTCGGCAAAACAGAACTTTCTAAACAACTAGCGATTGAGCTCTTTGGTTCAGC
TGACAGCATGATTCGTTTTGATATGAGTGAGTATATGGAAAAACATAGCGTAGCAAAACTCGTCGGAGCGCCTCCAGGTT
ACGTTGGCTACGAAGAAGCTGGACAATTAACAGAACGTGTACGTCGTAATCCTTATTCTCTCATTTTACTTGATGAAATA
GAAAAAGCTCACCCAGATGTCATGCACATGTTCTTGCAAGTACTGGATGACGGACGTCTGACAGATGGACAAGGTCGGAC
AGTCAGTTTCAAAGATACGATTATCATTATGACTTCCAACGCCGGTACTGGAAAAGTTGAGGCAAACGTCGGATTTGGTG
CAGCGCGTGAAGGACGAACCAATTCTGTTATCGGTGAATTAGGAGACTTCTTCAGTCCAGAATTTATGAATCGTTTCGAT
GGTATTATTGAGTTCAAATCTCTTAGCAAGGAAAATCTCCTACAAATCGTAGATTTGATGCTTGAAGATGTGAATAAACG
CTTAGCTGTAAATGGTATTCACCTAGACGTAACAGACAAAGTCAAGGAAAAATTAGTTAATCTTGGTTACGATCCAAAAA
TGGGAGCTCGTCCACTTCGTCGGACAATCCAAGATCACATCGAGGATGCTATCACCGACTACTATCTTGAACATCCAAGC
GAAAAAGAGCTCAAAGCTGTCATGACGAGCAATAGCAAGATTGTTATCAAGTCGTCCAAAAAGTCTGAAAACGAGACCGA
AAAAGAAATTAAAACAACAGCAGACGACACTGCTAACTGA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(292-389)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(648-722)

ATPase family associated with various cellular activities (AAA) (AAA)

(154-273)

AAA domain (Cdc48 subfamily) (AAA_2)

(477-640)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.968

99.078

0.862
  clpE Streptococcus pneumoniae D39

86.968

99.078

0.862
  clpE Streptococcus pneumoniae R6

86.968

99.078

0.862
  clpE Streptococcus pneumoniae TIGR4

86.835

99.078

0.86
  clpE Streptococcus mutans UA159

84.321

100

0.843
  clpC Lactococcus lactis subsp. cremoris KW2

76.222

99.736

0.76
  clpC Bacillus subtilis subsp. subtilis str. 168

49.857

91.963

0.459
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.546

85.903

0.408
  clpC Streptococcus pneumoniae Rx1

48.071

81.95

0.394
  clpC Streptococcus pneumoniae D39

48.071

81.95

0.394
  clpC Streptococcus pneumoniae TIGR4

47.91

81.95

0.393
  clpC Streptococcus mutans UA159

46.955

82.213

0.386
  clpC Streptococcus thermophilus LMG 18311

46.795

82.213

0.385
  clpC Streptococcus thermophilus LMD-9

46.87

82.082

0.385

Multiple sequence alignment