Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   EL092_RS03465 Genome accession   NZ_LR134291
Coordinates   730296..732557 (-) Length   753 a.a.
NCBI ID   WP_012000161.1    Uniprot ID   A8AW30
Organism   Streptococcus gordonii strain NCTC7868     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 725296..737557
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL092_RS03435 (NCTC7868_00683) - 726727..727143 (-) 417 WP_012000156.1 MarR family winged helix-turn-helix transcriptional regulator -
  EL092_RS03440 (NCTC7868_00685) - 727205..727643 (+) 439 Protein_663 GNAT family N-acetyltransferase -
  EL092_RS03445 (NCTC7868_00686) - 727681..727980 (-) 300 WP_012000157.1 DUF1827 family protein -
  EL092_RS03450 (NCTC7868_00687) - 728079..728531 (-) 453 WP_012000158.1 NUDIX hydrolase -
  EL092_RS03455 (NCTC7868_00688) - 728690..729580 (+) 891 WP_012000159.1 helix-turn-helix transcriptional regulator -
  EL092_RS03460 (NCTC7868_00689) - 729640..730245 (+) 606 WP_012000160.1 GyrI-like domain-containing protein -
  EL092_RS03465 (NCTC7868_00690) clpE 730296..732557 (-) 2262 WP_012000161.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  EL092_RS03470 (NCTC7868_00691) - 732811..733041 (+) 231 WP_008809091.1 DUF1797 family protein -
  EL092_RS03475 (NCTC7868_00692) - 733175..734029 (+) 855 WP_012000162.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  EL092_RS03480 (NCTC7868_00693) - 734026..734799 (+) 774 WP_012000163.1 HAD hydrolase family protein -
  EL092_RS03485 (NCTC7868_00694) - 734907..735749 (+) 843 WP_012000164.1 NAD(P)H-hydrate dehydratase -
  EL092_RS10910 - 735725..735961 (+) 237 Protein_673 initiator RepB protein -
  EL092_RS03495 (NCTC7868_00695) xseA 735906..737246 (+) 1341 WP_012000165.1 exodeoxyribonuclease VII large subunit -
  EL092_RS03500 (NCTC7868_00696) - 737224..737436 (+) 213 WP_008809086.1 exodeoxyribonuclease VII small subunit -

Sequence

Protein


Download         Length: 753 a.a.        Molecular weight: 83952.99 Da        Isoelectric Point: 5.0233

>NTDB_id=1120352 EL092_RS03465 WP_012000161.1 730296..732557(-) (clpE) [Streptococcus gordonii strain NCTC7868]
MLCQNCKINESTIHLYTNVNGKKQQVDLCQNCYQIMKTDPNNSLLSGLTNMNNHNMDPFDDFFNHLGNFQGPKDSTPPTQ
SGGSYGGGNYGPGSNNQHPQSASNKPKGLLEEFGINVTEIARRGDIDPVIGRDDEIRRVIEILNRRTKNNPVLIGEPGVG
KTAVVEGLAQKIVDSDVPQKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRNRNDIILFIDEIHEIVGAGSAGDG
NMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVRYTDEAIEA
AAILSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFVDPKEIDRRLIEAENLKTQATRDEDYEKAAYFRDQIAKYKEMQNA
KIDEQDTPIISEKEIEAIVEQKTNIPVGDLKEKEQSQLIHLASDLKSHVIGQDDAVDKIAKAIRRNRVGLGSPNRPIGSF
LFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILLDEVEK
AHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAREGRTNSVLGELGNFFSPEFMNRFDGI
IEFKALSKDNLLQIVDLMLEDVNNRLASNEIHLDVTAKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDYYLEHPKDK
DLKAIMTSNGKIIIKGKQKSELDQTTDISTSSD

Nucleotide


Download         Length: 2262 bp        

>NTDB_id=1120352 EL092_RS03465 WP_012000161.1 730296..732557(-) (clpE) [Streptococcus gordonii strain NCTC7868]
ATGCTTTGCCAAAACTGTAAAATCAATGAATCTACCATTCATTTATATACTAATGTTAATGGTAAAAAACAACAAGTCGA
CCTCTGTCAAAATTGCTATCAGATTATGAAAACTGATCCAAATAACTCTCTTTTGAGTGGACTGACGAACATGAACAATC
ATAATATGGATCCTTTTGATGATTTCTTTAATCATCTGGGGAATTTCCAAGGGCCGAAGGATTCTACCCCTCCAACTCAG
TCAGGTGGTAGTTACGGAGGGGGCAACTATGGTCCTGGTTCTAACAACCAGCATCCTCAGTCAGCTTCCAATAAACCAAA
AGGTCTTTTGGAAGAGTTTGGCATTAACGTTACAGAAATTGCTCGACGTGGTGATATTGATCCAGTGATTGGACGAGATG
ATGAAATTCGTCGTGTTATAGAAATTCTCAATCGCCGAACTAAGAATAATCCAGTCCTTATTGGCGAACCTGGTGTCGGC
AAGACTGCTGTTGTAGAGGGCTTGGCACAGAAAATAGTCGATAGTGACGTTCCTCAAAAACTGCAAGGAAAAGAGGTCAT
TCGGCTCGATGTTGTCAGCCTTGTTCAAGGAACTGGTATTCGTGGACAGTTTGAAGAACGAATGCAAAAACTCATGGATG
AGATTCGCAATCGCAATGATATCATTCTCTTTATTGATGAAATCCATGAAATTGTTGGAGCTGGCTCTGCGGGCGACGGT
AATATGGATGCTGGAAATATTCTCAAACCTGCTCTTGCTCGAGGTGAACTTCAACTGGTCGGAGCTACTACTCTCAATGA
ATATCGTATCATTGAAAAAGATGCAGCTTTAGAAAGACGGATGCAACCAGTCAAGGTAGATGAACCAACCGTAGAAGAAA
CGATCACAATTCTAAAGGGAATTCAAAAGAAATACGAAGATTACCACCATGTTCGCTACACAGATGAAGCTATTGAAGCT
GCTGCCATCCTATCCAATCGTTATATTCAGGACCGTTTCCTTCCCGATAAAGCTATTGATCTTTTGGATGAATCAGGATC
TAAGATGAACCTAACCCTCAATTTTGTTGATCCAAAGGAAATTGACAGACGCTTGATAGAGGCTGAAAACCTTAAAACCC
AGGCCACTCGTGATGAAGATTATGAAAAGGCAGCCTACTTCCGTGACCAAATAGCTAAATATAAGGAAATGCAAAATGCT
AAAATAGATGAGCAAGATACTCCTATCATCAGTGAAAAGGAGATCGAGGCTATTGTTGAGCAAAAAACAAATATTCCTGT
TGGGGATTTGAAGGAAAAAGAGCAGTCTCAGCTTATTCATTTGGCTAGTGATTTGAAGTCTCATGTCATTGGACAGGATG
ATGCAGTTGATAAGATTGCAAAAGCTATCCGCCGTAATCGTGTGGGATTAGGCAGTCCAAACCGGCCAATCGGAAGTTTC
CTTTTTGTTGGACCGACTGGCGTTGGAAAAACTGAACTTTCCAAACAATTGGCCATCGAACTTTTTGGCTCTGCCGATAG
CATGATTCGTTTTGATATGAGTGAATACATGGAAAAACATAGCGTTGCCAAACTTGTGGGAGCACCTCCAGGTTACGTTG
GCTATGAAGAAGCAGGCCAGTTGACTGAACGTGTTCGTCGTAATCCATACTCACTCATTCTCTTAGACGAGGTAGAAAAA
GCCCATCCAGATGTCATGCATATGTTCTTACAAGTCCTGGATGACGGACGTTTGACTGATGGACAAGGACGAACAGTCAG
CTTCAAAGATACCATTATCATTATGACTTCCAATGCAGGAACTGGCAAAGTAGAAGCTAGCGTTGGCTTTGGTGCTGCTC
GAGAAGGTCGGACAAATTCTGTCTTAGGTGAGTTAGGTAACTTCTTTAGTCCTGAATTCATGAACCGATTTGATGGCATC
ATTGAATTCAAGGCATTAAGTAAGGATAATCTCTTACAGATTGTGGATCTAATGCTGGAAGATGTTAACAATAGACTTGC
TAGCAACGAAATTCATCTAGATGTAACAGCTAAAGTCAAAGAAAAATTGGTTGATCTGGGCTACGATCCTAAGATGGGGG
CACGACCACTCCGCCGAACCATTCAGGACCATATCGAAGATGCTATTACGGACTACTACCTAGAACATCCGAAAGATAAG
GATTTAAAAGCAATTATGACTAGCAATGGCAAGATTATAATTAAGGGTAAACAGAAATCTGAGCTTGATCAAACAACTGA
CATCAGCACTAGCTCGGATTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(475-638)

ATPase family associated with various cellular activities (AAA) (AAA)

(152-271)

AAA lid domain (AAA_lid_9)

(290-387)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(646-717)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AW30

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.595

99.07

0.858
  clpE Streptococcus pneumoniae D39

86.595

99.07

0.858
  clpE Streptococcus pneumoniae R6

86.595

99.07

0.858
  clpE Streptococcus pneumoniae TIGR4

86.461

99.07

0.857
  clpE Streptococcus mutans UA159

85.121

99.07

0.843
  clpC Lactococcus lactis subsp. cremoris KW2

77.454

100

0.776
  clpC Bacillus subtilis subsp. subtilis str. 168

50.517

89.907

0.454
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.177

86.853

0.401
  clpC Streptococcus pneumoniae Rx1

47.84

83.001

0.397
  clpC Streptococcus pneumoniae D39

47.84

83.001

0.397
  clpC Streptococcus pneumoniae TIGR4

47.68

83.001

0.396
  clpC Streptococcus thermophilus LMD-9

44.985

87.384

0.393
  clpC Streptococcus thermophilus LMG 18311

45.038

86.985

0.392
  clpC Streptococcus mutans UA159

47.343

82.47

0.39

Multiple sequence alignment