Detailed information NTG1120103

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: EL070_RS03510
• Genome accession: NZ_LR134284
• Coordinates: 664275..666557 (-)
• Length: 760 a.a.
• NCBI ID: WP_111705691.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8232
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 659275..671557

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL070_RS03495 (NCTC8232_00690)	ileS	660274..663075 (+)	2802	WP_111705692.1	isoleucine--tRNA ligase	-
EL070_RS03500 (NCTC8232_00692)	-	663339..663641 (-)	303	WP_002983878.1	DUF1827 family protein	-
EL070_RS03505 (NCTC8232_00693)	-	663692..664147 (-)	456	WP_002989103.1	NUDIX hydrolase	-
EL070_RS03510 (NCTC8232_00694)	clpE	664275..666557 (-)	2283	WP_111705691.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
EL070_RS03515 (NCTC8232_00695)	-	666855..667085 (+)	231	WP_002983885.1	YkuJ family protein	-
EL070_RS03520 (NCTC8232_00696)	-	667212..667898 (+)	687	WP_011018000.1	amino acid ABC transporter permease	-
EL070_RS03525 (NCTC8232_00697)	-	667898..668632 (+)	735	WP_126405126.1	amino acid ABC transporter ATP-binding protein	-
EL070_RS03530 (NCTC8232_00698)	-	668781..670190 (+)	1410	WP_111705689.1	cryptochrome/photolyase family protein	-

Sequence

Protein

• Length: 760 a.a.
• Molecular weight: 84719.86 Da
• Isoelectric Point: 4.9728

>NTDB_id=1120103 EL070_RS03510 WP_111705691.1 664275..666557(-) (clpE) [Streptococcus pyogenes strain NCTC8232]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPTNSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide

• Length: 2283 bp

>NTDB_id=1120103 EL070_RS03510 WP_111705691.1 664275..666557(-) (clpE) [Streptococcus pyogenes strain NCTC8232]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTACTAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAACCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTATTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGTGGTGAGTT
GCAACTCGTTGGTGCTACTACCTTAAATGAATACCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCTGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCGTTAATTTGGCTAATG
ATTTGAAAGCTCACGTGATTGGCCAAGATGATGCCGTTGACAAAATTGCCAAGGCCATTCGCCGGAACCGTGTGGGATTG
GGAACTCCAAATCGTCCTATTGGTTCTTTCCTATTCGTTGGGCCAACAGGTGTTGGTAAAACAGAGTTGTCTAAGCAACT
AGCTATTGAACTCTTTGGCTCTGCTGACAATATGATTCGCTTTGATATGTCCGAATACATGGAAAAACATGCCGTTGCTA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCTTAT
TCCCTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGACGGTCG
CTTAACAGACGGCCAAGGGCGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAACATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTAGATTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (300-397)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-729)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.893	98.421	0.836
clpE	Streptococcus pneumoniae Rx1	82.956	98.816	0.82
clpE	Streptococcus pneumoniae D39	82.956	98.816	0.82
clpE	Streptococcus pneumoniae R6	82.956	98.816	0.82
clpE	Streptococcus pneumoniae TIGR4	82.823	98.816	0.818
clpC	Lactococcus lactis subsp. cremoris KW2	75.164	100	0.753
clpC	Bacillus subtilis subsp. subtilis str. 168	51.593	86.711	0.447
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.154	85.526	0.395
clpC	Streptococcus pneumoniae Rx1	47.84	82.237	0.393
clpC	Streptococcus pneumoniae D39	47.84	82.237	0.393
clpC	Streptococcus pneumoniae TIGR4	47.84	82.237	0.393
clpC	Streptococcus mutans UA159	47.573	81.316	0.387
clpC	Streptococcus thermophilus LMD-9	47.115	82.105	0.387
clpC	Streptococcus thermophilus LMG 18311	46.795	82.105	0.384