Detailed information NTG1120102

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EL070_RS03390
• Genome accession: NZ_LR134284
• Coordinates: 639822..640859 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8232
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 634822..645859

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL070_RS03365 (NCTC8232_00664)	-	635086..636417 (+)	1332	WP_111705700.1	dipeptidase	-
EL070_RS03370 (NCTC8232_00665)	arcC	636437..637387 (+)	951	WP_111705699.1	carbamate kinase	-
EL070_RS03375 (NCTC8232_00666)	asnA	637700..638692 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
EL070_RS03380 (NCTC8232_00667)	rsmD	638815..639354 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EL070_RS03385 (NCTC8232_00668)	coaD	639344..639835 (+)	492	WP_111705698.1	pantetheine-phosphate adenylyltransferase	-
EL070_RS03390 (NCTC8232_00669)	sepM	639822..640859 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
EL070_RS03395 (NCTC8232_00670)	-	641270..642247 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
EL070_RS03400 (NCTC8232_00671)	-	642695..643315 (+)	621	WP_002992791.1	YutD family protein	-
EL070_RS03405 (NCTC8232_00672)	rlmN	643319..644398 (+)	1080	WP_126405124.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
EL070_RS03410 (NCTC8232_00673)	-	644480..645106 (-)	627	WP_111705697.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1120102 EL070_RS03390 WP_010922499.1 639822..640859(+) (sepM) [Streptococcus pyogenes strain NCTC8232]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1120102 EL070_RS03390 WP_010922499.1 639822..640859(+) (sepM) [Streptococcus pyogenes strain NCTC8232]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCGGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693