Detailed information NTG1118858

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EL036_RS10005
• Genome accession: NZ_LR134193
• Coordinates: 1975777..1976820 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC13616
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1970777..1981820

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL036_RS09975 (NCTC13616_01920)	-	1971198..1972454 (-)	1257	WP_075583716.1	aminopeptidase	-
EL036_RS09980 (NCTC13616_01921)	-	1972457..1972657 (-)	201	WP_000180460.1	DUF1128 family protein	-
EL036_RS09985 (NCTC13616_01922)	-	1972804..1973268 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EL036_RS09990 (NCTC13616_01923)	-	1973275..1973550 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
EL036_RS09995 (NCTC13616_01924)	-	1973828..1975045 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
EL036_RS10000 (NCTC13616_01925)	vraR	1975158..1975787 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
EL036_RS10005 (NCTC13616_01926)	vraS	1975777..1976820 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EL036_RS10010 (NCTC13616_01927)	liaF	1976817..1977518 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EL036_RS10015 (NCTC13616_01928)	-	1977533..1977919 (-)	387	WP_001110179.1	hypothetical protein	-
EL036_RS10020 (NCTC13616_01929)	map	1978136..1978894 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EL036_RS10025 (NCTC13616_01930)	-	1979423..1980409 (+)	987	WP_000999713.1	FUSC family protein	-
EL036_RS10035 (NCTC13616_01931)	-	1980840..1981253 (-)	414	WP_001670387.1	hypothetical protein	-
EL036_RS10040	-	1981282..1981392 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1118858 EL036_RS10005 WP_001017131.1 1975777..1976820(-) (vraS) [Staphylococcus aureus strain NCTC13616]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1118858 EL036_RS10005 WP_001017131.1 1975777..1976820(-) (vraS) [Staphylococcus aureus strain NCTC13616]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1