Detailed information NTG1118242

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ELZ56_RS09975
• Genome accession: NZ_LR134093
• Coordinates: 1982071..1983114 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC11965
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1977071..1988114

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ELZ56_RS09945 (NCTC11965_01887)	-	1977492..1978748 (-)	1257	WP_001793983.1	aminopeptidase	-
ELZ56_RS09950 (NCTC11965_01888)	-	1978751..1978951 (-)	201	WP_000180460.1	DUF1128 family protein	-
ELZ56_RS09955 (NCTC11965_01889)	-	1979098..1979562 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
ELZ56_RS09960 (NCTC11965_01890)	-	1979569..1979844 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ELZ56_RS09965 (NCTC11965_01891)	-	1980122..1981339 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ELZ56_RS09970 (NCTC11965_01892)	vraR	1981452..1982081 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ELZ56_RS09975 (NCTC11965_01893)	vraS	1982071..1983114 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ELZ56_RS09980 (NCTC11965_01894)	liaF	1983111..1983812 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ELZ56_RS09985 (NCTC11965_01895)	-	1983827..1984213 (-)	387	WP_001110178.1	hypothetical protein	-
ELZ56_RS09990 (NCTC11965_01896)	map	1984430..1985188 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ELZ56_RS09995 (NCTC11965_01897)	-	1985774..1986760 (+)	987	WP_001014423.1	FUSC family protein	-
ELZ56_RS10000 (NCTC11965_01898)	-	1986949..1987362 (-)	414	WP_001643743.1	hypothetical protein	-
ELZ56_RS10005	-	1987391..1987501 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1118242 ELZ56_RS09975 WP_001017131.1 1982071..1983114(-) (vraS) [Staphylococcus aureus strain NCTC11965]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1118242 ELZ56_RS09975 WP_001017131.1 1982071..1983114(-) (vraS) [Staphylococcus aureus strain NCTC11965]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGTGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1