Detailed information NTG1118016

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ELZ49_RS10090
• Genome accession: NZ_LR134086
• Coordinates: 1986253..1987296 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC13142
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1981253..1992296

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ELZ49_RS10060 (NCTC13142_01953)	-	1981674..1982930 (-)	1257	WP_075583716.1	aminopeptidase	-
ELZ49_RS10065 (NCTC13142_01954)	-	1982933..1983133 (-)	201	WP_000180460.1	DUF1128 family protein	-
ELZ49_RS10070 (NCTC13142_01955)	-	1983280..1983744 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ELZ49_RS10075 (NCTC13142_01956)	-	1983751..1984026 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ELZ49_RS10080 (NCTC13142_01957)	-	1984304..1985521 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ELZ49_RS10085 (NCTC13142_01958)	vraR	1985634..1986263 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ELZ49_RS10090 (NCTC13142_01959)	vraS	1986253..1987296 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ELZ49_RS10095 (NCTC13142_01960)	liaF	1987293..1987994 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ELZ49_RS10100 (NCTC13142_01961)	-	1988009..1988395 (-)	387	WP_001110179.1	hypothetical protein	-
ELZ49_RS10105 (NCTC13142_01962)	map	1988612..1989370 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ELZ49_RS10110 (NCTC13142_01963)	-	1989898..1990884 (+)	987	WP_000999713.1	FUSC family protein	-
ELZ49_RS10120 (NCTC13142_01964)	-	1991315..1991728 (-)	414	WP_001670387.1	hypothetical protein	-
ELZ49_RS10125	-	1991757..1991867 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1118016 ELZ49_RS10090 WP_001017131.1 1986253..1987296(-) (vraS) [Staphylococcus aureus strain NCTC13142]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1118016 ELZ49_RS10090 WP_001017131.1 1986253..1987296(-) (vraS) [Staphylococcus aureus strain NCTC13142]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1