Detailed information NTG1116963

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EW031_RS10710
• Genome accession: NZ_LR130518
• Coordinates: 2044302..2045345 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BPH2986 isolate BPH2986
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2039302..2050345

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW031_RS10680	-	2039720..2040976 (-)	1257	WP_001795438.1	aminopeptidase	-
EW031_RS10685	-	2040979..2041179 (-)	201	WP_000180461.1	DUF1128 family protein	-
EW031_RS10690	-	2041326..2041790 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EW031_RS10695	-	2041797..2042072 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
EW031_RS10700	-	2042350..2043567 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
EW031_RS10705	vraR	2043683..2044312 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
EW031_RS10710	vraS	2044302..2045345 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EW031_RS10715	liaF	2045342..2046043 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EW031_RS10720	-	2046058..2046444 (-)	387	WP_001110179.1	hypothetical protein	-
EW031_RS10725	map	2046661..2047419 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EW031_RS10740	-	2047947..2048933 (+)	987	WP_000999713.1	FUSC family protein	-
EW031_RS10750	-	2049423..2049836 (-)	414	WP_001549145.1	hypothetical protein	-
EW031_RS10755	-	2049865..2049975 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1116963 EW031_RS10710 WP_001017131.1 2044302..2045345(-) (vraS) [Staphylococcus aureus strain BPH2986 isolate BPH2986]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1116963 EW031_RS10710 WP_001017131.1 2044302..2045345(-) (vraS) [Staphylococcus aureus strain BPH2986 isolate BPH2986]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1