Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | EW033_RS00525 | Genome accession | NZ_LR130515 |
| Coordinates | 97576..98922 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain BPH2947 isolate BPH2947 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 40374..98922 | 97576..98922 | within | 0 |
Gene organization within MGE regions
Location: 40374..98922
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EW033_RS00175 | ccrC | 40374..42059 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| EW033_RS00180 | tnpA | 42107..42592 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| EW033_RS00185 | - | 42884..43222 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| EW033_RS00195 | - | 43316..43627 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| EW033_RS00200 | - | 43643..44149 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| EW033_RS00205 | - | 44170..44487 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| EW033_RS00210 | - | 44606..45691 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| EW033_RS00215 | - | 45688..47580 (+) | 1893 | WP_014532403.1 | site-specific integrase | - |
| EW033_RS00220 | - | 47587..47964 (+) | 378 | WP_001041907.1 | DUF6262 family protein | - |
| EW033_RS00225 | - | 48115..48897 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| EW033_RS00230 | erm(A) | 49023..49754 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| EW033_RS16645 | - | 49812..49871 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| EW033_RS00245 | - | 50263..50925 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| EW033_RS16460 | - | 51157..51303 (+) | 147 | Protein_43 | JAB domain-containing protein | - |
| EW033_RS00255 | - | 51473..52345 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| EW033_RS00260 | - | 52402..52692 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| EW033_RS00265 | - | 52708..53196 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| EW033_RS00270 | - | 53331..53858 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| EW033_RS00275 | - | 53920..54336 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| EW033_RS16330 | - | 54625..54789 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| EW033_RS00280 | - | 54803..55024 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| EW033_RS00285 | - | 55174..55740 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| EW033_RS00290 | - | 55820..58033 (-) | 2214 | Protein_52 | type I restriction endonuclease subunit R | - |
| EW033_RS00295 | - | 58095..58769 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| EW033_RS00300 | - | 59052..60398 (+) | 1347 | WP_064221817.1 | dihydrolipoyl dehydrogenase family protein | - |
| EW033_RS00305 | merR | 60698..61105 (+) | 408 | WP_000525462.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| EW033_RS00310 | - | 61106..61606 (+) | 501 | WP_129760446.1 | TlpA family protein disulfide reductase | - |
| EW033_RS00315 | - | 61603..62283 (+) | 681 | WP_000010351.1 | cytochrome c biogenesis CcdA family protein | - |
| EW033_RS00320 | - | 62418..62756 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| EW033_RS00325 | merA | 62814..64457 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| EW033_RS00330 | merB | 64539..65189 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| EW033_RS00340 | - | 65384..65899 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| EW033_RS00345 | - | 66018..66692 (-) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| EW033_RS00350 | - | 67027..68199 (-) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| EW033_RS16650 | - | 68457..68789 (-) | 333 | WP_001803416.1 | DUF3021 domain-containing protein | - |
| EW033_RS00365 | - | 68818..69060 (-) | 243 | WP_001803415.1 | LytTR family DNA-binding domain-containing protein | - |
| EW033_RS00370 | - | 69192..69866 (-) | 675 | WP_072387114.1 | IS6-like element IS257 family transposase | - |
| EW033_RS00375 | tet(K) | 70063..71442 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| EW033_RS00380 | mobV | 71631..72872 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| EW033_RS00385 | - | 73399..74353 (+) | 955 | Protein_69 | replication initiation factor domain-containing protein | - |
| EW033_RS00390 | - | 74442..75116 (-) | 675 | WP_001105987.1 | IS6-like element IS257 family transposase | - |
| EW033_RS00395 | - | 75152..75541 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| EW033_RS00405 | - | 76498..77241 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| EW033_RS00410 | - | 77338..77766 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| EW033_RS00415 | mecA | 77812..79821 (-) | 2010 | WP_078056052.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| EW033_RS00420 | mecR1 | 79918..81675 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| EW033_RS00425 | mecI | 81675..82046 (+) | 372 | Protein_76 | mecA-type methicillin resistance repressor MecI | - |
| EW033_RS00430 | psm-mec | 82131..82199 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| EW033_RS00435 | - | 82519..83667 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| EW033_RS00440 | cstB | 83781..85115 (-) | 1335 | Protein_79 | persulfide dioxygenase-sulfurtransferase CstB | - |
| EW033_RS00445 | - | 85147..86211 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| EW033_RS00450 | cstR | 86347..86607 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| EW033_RS00455 | - | 86607..87245 (+) | 639 | Protein_82 | sulfite exporter TauE/SafE family protein | - |
| EW033_RS00465 | - | 87519..88136 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| EW033_RS00470 | - | 88217..90631 (-) | 2415 | WP_000378486.1 | cadmium-translocating P-type ATPase CadA | - |
| EW033_RS00475 | - | 90624..90989 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| EW033_RS00480 | - | 91175..91552 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| EW033_RS00485 | - | 91559..93451 (-) | 1893 | WP_014532403.1 | site-specific integrase | - |
| EW033_RS00490 | - | 93646..93969 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| EW033_RS00495 | - | 93962..94168 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| EW033_RS00500 | - | 94170..94691 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| EW033_RS00505 | - | 94710..95021 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| EW033_RS00515 | - | 95106..95456 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| EW033_RS00520 | ccrB | 95927..97555 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| EW033_RS00525 | ccrA | 97576..98922 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=1116887 EW033_RS00525 WP_000816499.1 97576..98922(-) (ccrA) [Staphylococcus aureus strain BPH2947 isolate BPH2947]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=1116887 EW033_RS00525 WP_000816499.1 97576..98922(-) (ccrA) [Staphylococcus aureus strain BPH2947 isolate BPH2947]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |