Detailed information NTG1116876

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EW029_RS09935
• Genome accession: NZ_LR130513
• Coordinates: 1966048..1967091 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BPH2900 isolate BPH2900
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1961048..1972091

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW029_RS09905	-	1961469..1962725 (-)	1257	WP_075583716.1	aminopeptidase	-
EW029_RS09910	-	1962728..1962928 (-)	201	WP_000180460.1	DUF1128 family protein	-
EW029_RS09915	-	1963075..1963539 (+)	465	WP_129654709.1	low molecular weight protein-tyrosine-phosphatase	-
EW029_RS09920	-	1963546..1963821 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
EW029_RS09925	-	1964099..1965316 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
EW029_RS09930	vraR	1965429..1966058 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
EW029_RS09935	vraS	1966048..1967091 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EW029_RS09940	liaF	1967088..1967789 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EW029_RS09945	-	1967804..1968190 (-)	387	WP_001110179.1	hypothetical protein	-
EW029_RS09950	map	1968407..1969165 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EW029_RS09955	-	1969636..1970622 (+)	987	WP_000999713.1	FUSC family protein	-
EW029_RS09965	-	1971053..1971466 (-)	414	WP_001670387.1	hypothetical protein	-
EW029_RS09970	-	1971495..1971605 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1116876 EW029_RS09935 WP_001017131.1 1966048..1967091(-) (vraS) [Staphylococcus aureus strain BPH2900 isolate BPH2900]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1116876 EW029_RS09935 WP_001017131.1 1966048..1967091(-) (vraS) [Staphylococcus aureus strain BPH2900 isolate BPH2900]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1