Detailed information NTG1116219

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: EQB41_RS10140
• Genome accession: NZ_LR129840
• Coordinates: 1878335..1879372 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 4496 isolate 4496
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1873335..1884372

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQB41_RS10115	-	1874074..1875405 (-)	1332	WP_000390039.1	hemolysin family protein	-
EQB41_RS10120	endA	1875696..1876520 (-)	825	WP_001036790.1	DNA-entry nuclease EndA	Machinery gene
EQB41_RS10125	-	1876559..1876747 (-)	189	WP_001818955.1	DNA-directed RNA polymerase subunit beta	-
EQB41_RS10130	murA	1876740..1878023 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
EQB41_RS10135	-	1878047..1878277 (-)	231	WP_000250391.1	DUF1146 family protein	-
EQB41_RS10140	sepM	1878335..1879372 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
EQB41_RS10145	coaD	1879356..1879844 (-)	489	WP_001280723.1	pantetheine-phosphate adenylyltransferase	-
EQB41_RS10150	rsmD	1879834..1880373 (-)	540	WP_000706964.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
EQB41_RS10155	asnA	1880438..1881430 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
EQB41_RS10165	-	1881542..1882225 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
EQB41_RS10170	-	1882281..1883021 (-)	741	WP_000152678.1	TrmH family RNA methyltransferase	-
EQB41_RS10175	-	1883055..1883333 (+)	279	WP_001174613.1	acylphosphatase	-
EQB41_RS10180	yidC	1883411..1884337 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=1116219 EQB41_RS10140 WP_000727277.1 1878335..1879372(-) (sepM) [Streptococcus pneumoniae strain 4496 isolate 4496]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=1116219 EQB41_RS10140 WP_000727277.1 1878335..1879372(-) (sepM) [Streptococcus pneumoniae strain 4496 isolate 4496]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGGAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591