Detailed information NTG1115975

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E0E12_RS10625
• Genome accession: NZ_LR027876
• Coordinates: 2033470..2034513 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JKD6009 isolate JKD6009
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2028470..2039513

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0E12_RS10595	-	2028888..2030144 (-)	1257	WP_001795438.1	aminopeptidase	-
E0E12_RS10600	-	2030147..2030347 (-)	201	WP_000180461.1	DUF1128 family protein	-
E0E12_RS10605	-	2030494..2030958 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E0E12_RS10610	-	2030965..2031240 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E0E12_RS10615	-	2031518..2032735 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E0E12_RS10620	vraR	2032851..2033480 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
E0E12_RS10625	vraS	2033470..2034513 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E0E12_RS10630	liaF	2034510..2035211 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E0E12_RS10635	-	2035226..2035612 (-)	387	WP_001110179.1	hypothetical protein	-
E0E12_RS10640	map	2035829..2036587 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E0E12_RS10650	-	2037174..2038160 (+)	987	WP_000999713.1	FUSC family protein	-
E0E12_RS10660	-	2038591..2039004 (-)	414	WP_001549145.1	hypothetical protein	-
E0E12_RS10665	-	2039033..2039143 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1115975 E0E12_RS10625 WP_001017131.1 2033470..2034513(-) (vraS) [Staphylococcus aureus strain JKD6009 isolate JKD6009]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1115975 E0E12_RS10625 WP_001017131.1 2033470..2034513(-) (vraS) [Staphylococcus aureus strain JKD6009 isolate JKD6009]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1