Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | E0E13_RS00510 | Genome accession | NZ_LR027874 |
| Coordinates | 94632..95978 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain BPH2056 isolate BPH2056 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 40375..95978 | 94632..95978 | within | 0 |
Gene organization within MGE regions
Location: 40375..95978
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E0E13_RS00175 | ccrC | 40375..42051 (+) | 1677 | WP_000676597.1 | cassette chromosome recombinase CcrC | - |
| E0E13_RS00180 | - | 42157..42495 (+) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| E0E13_RS00185 | - | 42591..42902 (+) | 312 | WP_001083108.1 | DUF960 family protein | - |
| E0E13_RS00190 | - | 42918..43424 (+) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| E0E13_RS00195 | - | 43445..43762 (+) | 318 | WP_130825069.1 | JAB domain-containing protein | - |
| E0E13_RS00200 | - | 43881..44966 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| E0E13_RS00205 | - | 44963..46855 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| E0E13_RS00210 | - | 46862..47239 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| E0E13_RS00215 | - | 47390..48172 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| E0E13_RS00220 | erm(A) | 48298..49029 (-) | 732 | WP_001072197.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| E0E13_RS16245 | - | 49087..49146 (-) | 60 | WP_181875734.1 | erythromycin resistance leader peptide | - |
| E0E13_RS00235 | - | 49538..50200 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| E0E13_RS16195 | - | 50432..50578 (+) | 147 | Protein_42 | JAB domain-containing protein | - |
| E0E13_RS00245 | - | 50748..51620 (+) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| E0E13_RS00250 | - | 51677..51967 (+) | 291 | WP_000065261.1 | hypothetical protein | - |
| E0E13_RS00255 | - | 51983..52471 (+) | 489 | WP_000393586.1 | hypothetical protein | - |
| E0E13_RS00260 | - | 52606..53133 (+) | 528 | WP_000717929.1 | hypothetical protein | - |
| E0E13_RS00265 | - | 53195..53638 (+) | 444 | WP_000941333.1 | hypothetical protein | - |
| E0E13_RS00270 | - | 53587..53808 (+) | 222 | WP_002504703.1 | hypothetical protein | - |
| E0E13_RS00280 | - | 54202..54525 (+) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| E0E13_RS00285 | - | 54603..56816 (-) | 2214 | Protein_50 | type I restriction endonuclease subunit R | - |
| E0E13_RS00290 | - | 56878..57552 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| E0E13_RS00295 | - | 57835..59181 (+) | 1347 | WP_000163428.1 | dihydrolipoyl dehydrogenase family protein | - |
| E0E13_RS00300 | merR | 59481..59888 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| E0E13_RS00305 | - | 59905..60258 (+) | 354 | WP_033842287.1 | TlpA family protein disulfide reductase | - |
| E0E13_RS00310 | - | 60255..60935 (+) | 681 | WP_033842288.1 | cytochrome c biogenesis CcdA family protein | - |
| E0E13_RS00315 | - | 61070..61408 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| E0E13_RS00320 | merA | 61466..63109 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| E0E13_RS00325 | merB | 63191..63841 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| E0E13_RS00335 | - | 64036..64566 (-) | 531 | WP_041205518.1 | hypothetical protein | - |
| E0E13_RS00340 | - | 64602..65276 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| E0E13_RS16250 | - | 65709..66041 (-) | 333 | WP_001803416.1 | DUF3021 domain-containing protein | - |
| E0E13_RS00350 | - | 66070..66312 (-) | 243 | WP_001803415.1 | LytTR family DNA-binding domain-containing protein | - |
| E0E13_RS00355 | - | 66444..67118 (-) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| E0E13_RS00360 | tet(K) | 67315..68694 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| E0E13_RS00365 | mobV | 68880..70121 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| E0E13_RS00370 | - | 70648..71602 (+) | 955 | Protein_66 | replication initiation factor domain-containing protein | - |
| E0E13_RS00375 | - | 71691..72365 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| E0E13_RS00380 | - | 72401..72790 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| E0E13_RS00390 | - | 73667..74410 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| E0E13_RS00395 | - | 74507..74935 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| E0E13_RS00400 | mecA | 74981..76990 (-) | 2010 | WP_078056515.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| E0E13_RS00405 | - | 77087..78678 (+) | 1592 | Protein_72 | BlaR1 family beta-lactam sensor/signal transducer | - |
| E0E13_RS00410 | mecI | 78678..79049 (+) | 372 | Protein_73 | mecA-type methicillin resistance repressor MecI | - |
| E0E13_RS00415 | psm-mec | 79134..79202 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| E0E13_RS00420 | - | 79522..80670 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| E0E13_RS00425 | cstB | 80784..82118 (-) | 1335 | Protein_76 | persulfide dioxygenase-sulfurtransferase CstB | - |
| E0E13_RS00430 | - | 82151..83215 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| E0E13_RS00435 | cstR | 83351..83611 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| E0E13_RS00440 | - | 83611..84249 (+) | 639 | Protein_79 | sulfite exporter TauE/SafE family protein | - |
| E0E13_RS00450 | - | 84523..85140 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| E0E13_RS00455 | - | 85221..87635 (-) | 2415 | WP_000378487.1 | cadmium-translocating P-type ATPase CadA | - |
| E0E13_RS00460 | - | 87628..87993 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| E0E13_RS00465 | - | 88231..88608 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| E0E13_RS00470 | - | 88615..90507 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| E0E13_RS00475 | - | 90702..91025 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| E0E13_RS00480 | - | 91018..91224 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| E0E13_RS00485 | - | 91226..91747 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| E0E13_RS00490 | - | 91766..92077 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| E0E13_RS00500 | - | 92162..92512 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| E0E13_RS00505 | ccrB | 92983..94611 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| E0E13_RS00510 | ccrA | 94632..95978 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=1115899 E0E13_RS00510 WP_000816499.1 94632..95978(-) (ccrA) [Staphylococcus aureus strain BPH2056 isolate BPH2056]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=1115899 E0E13_RS00510 WP_000816499.1 94632..95978(-) (ccrA) [Staphylococcus aureus strain BPH2056 isolate BPH2056]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |