Detailed information NTG1115889

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E0E08_RS10885
• Genome accession: NZ_LR027873
• Coordinates: 2089303..2090346 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain BPH2070 isolate BPH2070
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2084303..2095346

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E0E08_RS10855	-	2084648..2084848 (-)	201	WP_000180461.1	DUF1128 family protein	-
E0E08_RS10860	-	2084995..2085459 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E0E08_RS10865	-	2085466..2085741 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E0E08_RS10870	-	2085996..2087168 (+)	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
E0E08_RS10875	-	2087351..2088568 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E0E08_RS10880	vraR	2088684..2089313 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
E0E08_RS10885	vraS	2089303..2090346 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E0E08_RS10890	liaF	2090343..2091044 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E0E08_RS10895	-	2091059..2091445 (-)	387	WP_001110179.1	hypothetical protein	-
E0E08_RS10900	map	2091662..2092420 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E0E08_RS10910	-	2093007..2093993 (+)	987	WP_000999713.1	FUSC family protein	-
E0E08_RS10920	-	2094424..2094837 (-)	414	WP_001549145.1	hypothetical protein	-
E0E08_RS10925	-	2094866..2094976 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1115889 E0E08_RS10885 WP_001017131.1 2089303..2090346(-) (vraS) [Staphylococcus aureus strain BPH2070 isolate BPH2070]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1115889 E0E08_RS10885 WP_001017131.1 2089303..2090346(-) (vraS) [Staphylococcus aureus strain BPH2070 isolate BPH2070]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1