Detailed information NTG1113701

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SRS_RS10185
• Genome accession: NZ_LN626917
• Coordinates: 1997596..1998639 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ILRI_Eymole1/1 isolate Staphylococcus aureus isolate ILRI_Eymole1/1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1992596..2003639

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SRS_RS10155	-	1993017..1994273 (-)	1257	WP_078103544.1	aminopeptidase	-
SRS_RS10160	-	1994276..1994476 (-)	201	WP_000180460.1	DUF1128 family protein	-
SRS_RS10165	-	1994623..1995087 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
SRS_RS10170	-	1995094..1995369 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SRS_RS10175	-	1995647..1996864 (+)	1218	WP_045179336.1	YihY/virulence factor BrkB family protein	-
SRS_RS10180	vraR	1996977..1997606 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SRS_RS10185	vraS	1997596..1998639 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SRS_RS10190	liaF	1998636..1999337 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SRS_RS10195	-	1999352..1999738 (-)	387	WP_001110178.1	hypothetical protein	-
SRS_RS10200	map	1999955..2000713 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SRS_RS10205	-	2001298..2002284 (+)	987	WP_001014423.1	FUSC family protein	-
SRS_RS10210	-	2002473..2002886 (-)	414	WP_001643743.1	hypothetical protein	-
SRS_RS10215	-	2002915..2003025 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1113701 SRS_RS10185 WP_001017131.1 1997596..1998639(-) (vraS) [Staphylococcus aureus strain ILRI_Eymole1/1 isolate Staphylococcus aureus isolate ILRI_Eymole1/1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1113701 SRS_RS10185 WP_001017131.1 1997596..1998639(-) (vraS) [Staphylococcus aureus strain ILRI_Eymole1/1 isolate Staphylococcus aureus isolate ILRI_Eymole1/1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1