Detailed information NTG1111875

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPYH293_RS05595
• Genome accession: NZ_HG316453
• Coordinates: 1142793..1143830 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain H293
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1137793..1148830

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYH293_RS05575 (SPYH293_01141)	-	1138535..1139161 (+)	627	WP_002983834.1	prepilin peptidase	-
SPYH293_RS05580 (SPYH293_01142)	rlmN	1139243..1140322 (-)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
SPYH293_RS05585 (SPYH293_01143)	-	1140326..1140946 (-)	621	WP_002992791.1	YutD family protein	-
SPYH293_RS05590 (SPYH293_01144)	-	1141394..1142371 (-)	978	WP_053039060.1	LacI family DNA-binding transcriptional regulator	-
SPYH293_RS05595 (SPYH293_01145)	sepM	1142793..1143830 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
SPYH293_RS05600 (SPYH293_01146)	coaD	1143817..1144308 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
SPYH293_RS05605 (SPYH293_01147)	rsmD	1144298..1144837 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPYH293_RS05610 (SPYH293_01148)	asnA	1144960..1145952 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
SPYH293_RS05615 (SPYH293_01149)	arcC	1146265..1147215 (-)	951	WP_010922501.1	carbamate kinase	-
SPYH293_RS05620 (SPYH293_01150)	-	1147235..1148566 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1111875 SPYH293_RS05595 WP_010922499.1 1142793..1143830(-) (sepM) [Streptococcus pyogenes strain H293]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1111875 SPYH293_RS05595 WP_010922499.1 1142793..1143830(-) (sepM) [Streptococcus pyogenes strain H293]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693