Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   SPYH293_RS05240 Genome accession   NZ_HG316453
Coordinates   1068397..1070202 (-) Length   601 a.a.
NCBI ID   WP_011054652.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain H293     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1048167..1095236 1068397..1070202 within 0


Gene organization within MGE regions


Location: 1048167..1095236
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYH293_RS05150 (SPYH293_01057) - 1048205..1049479 (-) 1275 WP_020837316.1 polysaccharide deacetylase family protein -
  SPYH293_RS05155 (SPYH293_01058) - 1049574..1051001 (-) 1428 WP_011284931.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  SPYH293_RS05160 (SPYH293_01059) ptsP 1051186..1052919 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  SPYH293_RS05165 (SPYH293_01060) - 1052924..1053187 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  SPYH293_RS05170 (SPYH293_01061) - 1053580..1053798 (+) 219 WP_002989242.1 redoxin NrdH -
  SPYH293_RS05175 (SPYH293_01062) nrdE 1053818..1055977 (+) 2160 WP_031488773.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  SPYH293_RS05180 (SPYH293_01063) nrdF 1056310..1057269 (+) 960 WP_002987365.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  SPYH293_RS05185 (SPYH293_01064) - 1057331..1058557 (+) 1227 WP_021340858.1 chloride channel protein -
  SPYH293_RS08775 - 1058653..1059810 (+) 1158 Protein_991 IS3 family transposase -
  SPYH293_RS05205 (SPYH293_01068) - 1059902..1060597 (-) 696 WP_031488553.1 CPBP family intramembrane glutamic endopeptidase -
  SPYH293_RS05210 (SPYH293_01069) - 1060616..1061377 (-) 762 WP_031488552.1 DUF3169 family protein -
  SPYH293_RS05215 (SPYH293_01070) - 1061374..1061589 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  SPYH293_RS05220 (SPYH293_01072) alaS 1061929..1064547 (-) 2619 WP_031488551.1 alanine--tRNA ligase -
  SPYH293_RS05225 (SPYH293_01073) prsA 1064934..1065989 (-) 1056 WP_002984003.1 peptidylprolyl isomerase PrsA -
  SPYH293_RS05230 (SPYH293_01074) - 1066052..1066759 (-) 708 WP_002984000.1 O-methyltransferase -
  SPYH293_RS05235 (SPYH293_01075) - 1066825..1068021 (-) 1197 WP_002995765.1 OFA family MFS transporter -
  SPYH293_RS05240 (SPYH293_01076) pepF 1068397..1070202 (-) 1806 WP_011054652.1 oligoendopeptidase F Regulator
  SPYH293_RS05245 (SPYH293_01077) - 1070215..1071177 (-) 963 WP_053039058.1 competence protein CoiA -
  SPYH293_RS05250 (SPYH293_01078) - 1071473..1072189 (-) 717 WP_002995774.1 pseudouridine synthase -
  SPYH293_RS05255 (SPYH293_01079) nagB 1072308..1073012 (-) 705 WP_002995779.1 glucosamine-6-phosphate deaminase -
  SPYH293_RS05260 (SPYH293_01080) queA 1073214..1074242 (+) 1029 WP_031488549.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  SPYH293_RS05265 (SPYH293_01081) - 1074249..1075469 (+) 1221 WP_002983986.1 DUF3114 domain-containing protein -
  SPYH293_RS05270 (SPYH293_01082) - 1075623..1076213 (-) 591 WP_002983984.1 serine hydrolase -
  SPYH293_RS09045 - 1076210..1076437 (-) 228 WP_226316535.1 hypothetical protein -
  SPYH293_RS05280 (SPYH293_01083) - 1076438..1076671 (-) 234 WP_002983979.1 hypothetical protein -
  SPYH293_RS05285 (SPYH293_01084) sodA 1076838..1077443 (-) 606 WP_002983977.1 superoxide dismutase SodA -
  SPYH293_RS05290 (SPYH293_01085) holA 1077540..1078580 (-) 1041 WP_031488548.1 DNA polymerase III subunit delta -
  SPYH293_RS05295 (SPYH293_01086) - 1078651..1080894 (-) 2244 WP_031488547.1 DNA internalization-related competence protein ComEC/Rec2 -
  SPYH293_RS05300 (SPYH293_01087) - 1080875..1081537 (-) 663 WP_002983967.1 ComEA family DNA-binding protein -
  SPYH293_RS05305 (SPYH293_01088) - 1081737..1082477 (-) 741 WP_031488546.1 lysophospholipid acyltransferase family protein -
  SPYH293_RS05310 (SPYH293_01089) - 1082595..1083371 (+) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  SPYH293_RS05315 (SPYH293_01090) - 1083361..1083639 (+) 279 WP_011017953.1 GIY-YIG nuclease family protein -
  SPYH293_RS05320 (SPYH293_01091) - 1083663..1085663 (-) 2001 WP_053039059.1 potassium transporter Kup -
  SPYH293_RS05325 (SPYH293_01092) - 1085790..1087409 (-) 1620 WP_002989158.1 DEAD/DEAH box helicase -
  SPYH293_RS05330 (SPYH293_01093) - 1087716..1089260 (-) 1545 WP_031488544.1 peptide chain release factor 3 -
  SPYH293_RS05335 (SPYH293_01094) - 1089508..1090203 (-) 696 WP_031488543.1 TIGR02206 family membrane protein -
  SPYH293_RS05340 (SPYH293_01095) - 1090283..1091674 (-) 1392 WP_031488542.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  SPYH293_RS05345 (SPYH293_01096) - 1091865..1092911 (-) 1047 WP_002989146.1 D-alanine--D-alanine ligase -
  SPYH293_RS05350 (SPYH293_01097) recR 1093012..1093608 (-) 597 WP_002983939.1 recombination mediator RecR -
  SPYH293_RS09155 - 1093655..1093846 (-) 192 WP_002983936.1 hypothetical protein -
  SPYH293_RS05360 (SPYH293_01098) - 1094405..1095184 (-) 780 WP_014407680.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69341.19 Da        Isoelectric Point: 4.7093

>NTDB_id=1111872 SPYH293_RS05240 WP_011054652.1 1068397..1070202(-) (pepF) [Streptococcus pyogenes strain H293]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=1111872 SPYH293_RS05240 WP_011054652.1 1068397..1070202(-) (pepF) [Streptococcus pyogenes strain H293]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

71.215

100

0.712

Multiple sequence alignment