Detailed information NTG1110694

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HQV12_RS09995
• Genome accession: NZ_CP184658
• Coordinates: 2017146..2018189 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain B0417
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2012146..2023189

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HQV12_RS09965 (HQV12_09965)	-	2012564..2013820 (-)	1257	WP_001795438.1	aminopeptidase	-
HQV12_RS09970 (HQV12_09970)	-	2013823..2014023 (-)	201	WP_000180461.1	DUF1128 family protein	-
HQV12_RS09975 (HQV12_09975)	-	2014170..2014634 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HQV12_RS09980 (HQV12_09980)	-	2014641..2014916 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HQV12_RS09985 (HQV12_09985)	-	2015194..2016411 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HQV12_RS09990 (HQV12_09990)	vraR	2016527..2017156 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
HQV12_RS09995 (HQV12_09995)	vraS	2017146..2018189 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HQV12_RS10000 (HQV12_10000)	liaF	2018186..2018887 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HQV12_RS10005 (HQV12_10005)	-	2018902..2019288 (-)	387	WP_001110179.1	hypothetical protein	-
HQV12_RS10010 (HQV12_10010)	map	2019505..2020263 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HQV12_RS10015 (HQV12_10015)	-	2020791..2021777 (+)	987	WP_000999713.1	FUSC family protein	-
HQV12_RS10020 (HQV12_10020)	-	2022267..2022680 (-)	414	WP_001549145.1	hypothetical protein	-
HQV12_RS10025 (HQV12_10025)	-	2022709..2022819 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1110694 HQV12_RS09995 WP_001017131.1 2017146..2018189(-) (vraS) [Staphylococcus aureus strain B0417]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1110694 HQV12_RS09995 WP_001017131.1 2017146..2018189(-) (vraS) [Staphylococcus aureus strain B0417]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1