Detailed information NTG1109608

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACOCJA_RS00455
• Genome accession: NZ_CP184565
• Coordinates: 81158..82201 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CBTW2018043
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76158..87201

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACOCJA_RS00425 (ACOCJA_00425)	-	76773..76883 (+)	111	WP_014937049.1	hypothetical protein	-
ACOCJA_RS00430 (ACOCJA_00430)	-	76912..77325 (+)	414	WP_025174370.1	hypothetical protein	-
ACOCJA_RS00435 (ACOCJA_00435)	-	77514..78500 (-)	987	WP_420228253.1	FUSC family protein	-
ACOCJA_RS00440 (ACOCJA_00440)	map	79084..79842 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACOCJA_RS00445 (ACOCJA_00445)	-	80059..80445 (+)	387	WP_001110182.1	hypothetical protein	-
ACOCJA_RS00450 (ACOCJA_00450)	liaF	80460..81161 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACOCJA_RS00455 (ACOCJA_00455)	vraS	81158..82201 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACOCJA_RS00460 (ACOCJA_00460)	vraR	82191..82820 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACOCJA_RS00465 (ACOCJA_00465)	-	82933..84150 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACOCJA_RS00470 (ACOCJA_00470)	-	84428..84703 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACOCJA_RS00475 (ACOCJA_00475)	-	84710..85174 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACOCJA_RS00480 (ACOCJA_00480)	-	85321..85521 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACOCJA_RS00485 (ACOCJA_00485)	-	85524..86780 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1109608 ACOCJA_RS00455 WP_001017131.1 81158..82201(+) (vraS) [Staphylococcus aureus strain CBTW2018043]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1109608 ACOCJA_RS00455 WP_001017131.1 81158..82201(+) (vraS) [Staphylococcus aureus strain CBTW2018043]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATCAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1