Detailed information NTG1109556

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACOCJJ_RS09890
• Genome accession: NZ_CP184561
• Coordinates: 1988792..1989835 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CBTW2018311
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1983792..1994835

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACOCJJ_RS09860 (ACOCJJ_09860)	-	1984213..1985469 (-)	1257	WP_001793428.1	aminopeptidase	-
ACOCJJ_RS09865 (ACOCJJ_09865)	-	1985472..1985672 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACOCJJ_RS09870 (ACOCJJ_09870)	-	1985819..1986283 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACOCJJ_RS09875 (ACOCJJ_09875)	-	1986290..1986565 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACOCJJ_RS09880 (ACOCJJ_09880)	-	1986843..1988060 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACOCJJ_RS09885 (ACOCJJ_09885)	vraR	1988173..1988802 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACOCJJ_RS09890 (ACOCJJ_09890)	vraS	1988792..1989835 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACOCJJ_RS09895 (ACOCJJ_09895)	liaF	1989832..1990533 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACOCJJ_RS09900 (ACOCJJ_09900)	-	1990548..1990934 (-)	387	WP_001110182.1	hypothetical protein	-
ACOCJJ_RS09905 (ACOCJJ_09905)	map	1991151..1991909 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACOCJJ_RS09910 (ACOCJJ_09910)	-	1992493..1993479 (+)	987	WP_000999712.1	FUSC family protein	-
ACOCJJ_RS09915 (ACOCJJ_09915)	-	1993668..1994081 (-)	414	WP_025174370.1	hypothetical protein	-
ACOCJJ_RS09920 (ACOCJJ_09920)	-	1994110..1994220 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1109556 ACOCJJ_RS09890 WP_001017131.1 1988792..1989835(-) (vraS) [Staphylococcus aureus strain CBTW2018311]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1109556 ACOCJJ_RS09890 WP_001017131.1 1988792..1989835(-) (vraS) [Staphylococcus aureus strain CBTW2018311]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1