Detailed information NTG1109511

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACOCJH_RS09885
• Genome accession: NZ_CP184559
• Coordinates: 1990032..1991075 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CBTW2018367
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1985032..1996075

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACOCJH_RS09855 (ACOCJH_09855)	-	1985453..1986709 (-)	1257	WP_001793428.1	aminopeptidase	-
ACOCJH_RS09860 (ACOCJH_09860)	-	1986712..1986912 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACOCJH_RS09865 (ACOCJH_09865)	-	1987059..1987523 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACOCJH_RS09870 (ACOCJH_09870)	-	1987530..1987805 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACOCJH_RS09875 (ACOCJH_09875)	-	1988083..1989300 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACOCJH_RS09880 (ACOCJH_09880)	vraR	1989413..1990042 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACOCJH_RS09885 (ACOCJH_09885)	vraS	1990032..1991075 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACOCJH_RS09890 (ACOCJH_09890)	liaF	1991072..1991773 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACOCJH_RS09895 (ACOCJH_09895)	-	1991788..1992174 (-)	387	WP_001110182.1	hypothetical protein	-
ACOCJH_RS09900 (ACOCJH_09900)	map	1992391..1993149 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACOCJH_RS09905 (ACOCJH_09905)	-	1993733..1994719 (+)	987	WP_000999712.1	FUSC family protein	-
ACOCJH_RS09910 (ACOCJH_09910)	-	1994908..1995321 (-)	414	WP_025174370.1	hypothetical protein	-
ACOCJH_RS09915 (ACOCJH_09915)	-	1995350..1995460 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1109511 ACOCJH_RS09885 WP_001017131.1 1990032..1991075(-) (vraS) [Staphylococcus aureus strain CBTW2018367]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1109511 ACOCJH_RS09885 WP_001017131.1 1990032..1991075(-) (vraS) [Staphylococcus aureus strain CBTW2018367]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1