Detailed information NTG1109432

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACOCJB_RS00860
• Genome accession: NZ_CP184557
• Coordinates: 149765..150808 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SCTW2018482
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 144765..155808

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACOCJB_RS00830 (ACOCJB_00830)	-	145380..145490 (+)	111	WP_014937049.1	hypothetical protein	-
ACOCJB_RS00835 (ACOCJB_00835)	-	145519..145932 (+)	414	WP_025174370.1	hypothetical protein	-
ACOCJB_RS00840 (ACOCJB_00840)	-	146121..147107 (-)	987	WP_000999712.1	FUSC family protein	-
ACOCJB_RS00845 (ACOCJB_00845)	map	147691..148449 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACOCJB_RS00850 (ACOCJB_00850)	-	148666..149052 (+)	387	WP_001110182.1	hypothetical protein	-
ACOCJB_RS00855 (ACOCJB_00855)	liaF	149067..149768 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACOCJB_RS00860 (ACOCJB_00860)	vraS	149765..150808 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACOCJB_RS00865 (ACOCJB_00865)	vraR	150798..151427 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACOCJB_RS00870 (ACOCJB_00870)	-	151540..152757 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACOCJB_RS00875 (ACOCJB_00875)	-	153035..153310 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACOCJB_RS00880 (ACOCJB_00880)	-	153317..153781 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACOCJB_RS00885 (ACOCJB_00885)	-	153928..154128 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACOCJB_RS00890 (ACOCJB_00890)	-	154131..155387 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1109432 ACOCJB_RS00860 WP_001017131.1 149765..150808(+) (vraS) [Staphylococcus aureus strain SCTW2018482]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1109432 ACOCJB_RS00860 WP_001017131.1 149765..150808(+) (vraS) [Staphylococcus aureus strain SCTW2018482]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1