Detailed information NTG1109308

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACOCJC_RS06945
• Genome accession: NZ_CP184549
• Coordinates: 1394615..1395658 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SCTW2019145
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1389615..1400658

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACOCJC_RS06915 (ACOCJC_06915)	-	1390230..1390340 (+)	111	WP_014937049.1	hypothetical protein	-
ACOCJC_RS06920 (ACOCJC_06920)	-	1390369..1390782 (+)	414	WP_025174370.1	hypothetical protein	-
ACOCJC_RS06925 (ACOCJC_06925)	-	1390971..1391957 (-)	987	WP_000999712.1	FUSC family protein	-
ACOCJC_RS06930 (ACOCJC_06930)	map	1392541..1393299 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACOCJC_RS06935 (ACOCJC_06935)	-	1393516..1393902 (+)	387	WP_001110182.1	hypothetical protein	-
ACOCJC_RS06940 (ACOCJC_06940)	liaF	1393917..1394618 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACOCJC_RS06945 (ACOCJC_06945)	vraS	1394615..1395658 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACOCJC_RS06950 (ACOCJC_06950)	vraR	1395648..1396277 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACOCJC_RS06955 (ACOCJC_06955)	-	1396390..1397607 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACOCJC_RS06960 (ACOCJC_06960)	-	1397885..1398160 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACOCJC_RS06965 (ACOCJC_06965)	-	1398167..1398631 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACOCJC_RS06970 (ACOCJC_06970)	-	1398778..1398978 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACOCJC_RS06975 (ACOCJC_06975)	-	1398981..1400237 (+)	1257	WP_158109059.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1109308 ACOCJC_RS06945 WP_001017131.1 1394615..1395658(+) (vraS) [Staphylococcus aureus strain SCTW2019145]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1109308 ACOCJC_RS06945 WP_001017131.1 1394615..1395658(+) (vraS) [Staphylococcus aureus strain SCTW2019145]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1