Detailed information NTG1109254

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACOCJE_RS00455
• Genome accession: NZ_CP184547
• Coordinates: 81102..82145 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SCTW2021015
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76102..87145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACOCJE_RS00425 (ACOCJE_00425)	-	76772..76882 (+)	111	WP_014937049.1	hypothetical protein	-
ACOCJE_RS00430 (ACOCJE_00430)	-	76911..77324 (+)	414	WP_420228476.1	hypothetical protein	-
ACOCJE_RS00435 (ACOCJE_00435)	-	77513..78499 (-)	987	WP_000999712.1	FUSC family protein	-
ACOCJE_RS00440 (ACOCJE_00440)	map	79028..79786 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
ACOCJE_RS00445 (ACOCJE_00445)	-	80003..80389 (+)	387	WP_001110182.1	hypothetical protein	-
ACOCJE_RS00450 (ACOCJE_00450)	liaF	80404..81105 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACOCJE_RS00455 (ACOCJE_00455)	vraS	81102..82145 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACOCJE_RS00460 (ACOCJE_00460)	vraR	82135..82764 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACOCJE_RS00465 (ACOCJE_00465)	-	82877..84094 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
ACOCJE_RS00470 (ACOCJE_00470)	-	84372..84647 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACOCJE_RS00475 (ACOCJE_00475)	-	84654..85118 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACOCJE_RS00480 (ACOCJE_00480)	-	85265..85465 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACOCJE_RS00485 (ACOCJE_00485)	-	85468..86724 (+)	1257	WP_158109059.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1109254 ACOCJE_RS00455 WP_001017131.1 81102..82145(+) (vraS) [Staphylococcus aureus strain SCTW2021015]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1109254 ACOCJE_RS00455 WP_001017131.1 81102..82145(+) (vraS) [Staphylococcus aureus strain SCTW2021015]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1