Detailed information NTG1099351

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACM6AR_RS10130
• Genome accession: NZ_CP181164
• Coordinates: 2017267..2018310 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AG21-0620
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2012267..2023310

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACM6AR_RS10100 (ACM6AR_10100)	-	2012689..2013945 (-)	1257	WP_076692528.1	aminopeptidase	-
ACM6AR_RS10105 (ACM6AR_10105)	-	2013948..2014148 (-)	201	WP_416197088.1	DUF1128 domain-containing protein	-
ACM6AR_RS10110 (ACM6AR_10110)	-	2014295..2014759 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACM6AR_RS10115 (ACM6AR_10115)	-	2014766..2015041 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACM6AR_RS10120 (ACM6AR_10120)	-	2015319..2016536 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
ACM6AR_RS10125 (ACM6AR_10125)	vraR	2016648..2017277 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACM6AR_RS10130 (ACM6AR_10130)	vraS	2017267..2018310 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACM6AR_RS10135 (ACM6AR_10135)	liaF	2018307..2019008 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACM6AR_RS10140 (ACM6AR_10140)	-	2019023..2019409 (-)	387	WP_001110179.1	hypothetical protein	-
ACM6AR_RS10145 (ACM6AR_10145)	map	2019626..2020384 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACM6AR_RS10150 (ACM6AR_10150)	-	2020913..2021899 (+)	987	WP_000999713.1	FUSC family protein	-
ACM6AR_RS10155 (ACM6AR_10155)	-	2022330..2022743 (-)	414	WP_001670387.1	hypothetical protein	-
ACM6AR_RS10160 (ACM6AR_10160)	-	2022772..2022882 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1099351 ACM6AR_RS10130 WP_001017131.1 2017267..2018310(-) (vraS) [Staphylococcus aureus strain AG21-0620]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1099351 ACM6AR_RS10130 WP_001017131.1 2017267..2018310(-) (vraS) [Staphylococcus aureus strain AG21-0620]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1