Detailed information NTG1098925

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACM6AD_RS10035
• Genome accession: NZ_CP181138
• Coordinates: 2020228..2021271 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AG21-0601
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2015228..2026271

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACM6AD_RS10005 (ACM6AD_10005)	-	2015649..2016905 (-)	1257	WP_001795108.1	aminopeptidase	-
ACM6AD_RS10010 (ACM6AD_10010)	-	2016908..2017108 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACM6AD_RS10015 (ACM6AD_10015)	-	2017255..2017719 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACM6AD_RS10020 (ACM6AD_10020)	-	2017726..2018001 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACM6AD_RS10025 (ACM6AD_10025)	-	2018279..2019496 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACM6AD_RS10030 (ACM6AD_10030)	vraR	2019609..2020238 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACM6AD_RS10035 (ACM6AD_10035)	vraS	2020228..2021271 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACM6AD_RS10040 (ACM6AD_10040)	liaF	2021268..2021969 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACM6AD_RS10045 (ACM6AD_10045)	-	2021984..2022370 (-)	387	WP_001110179.1	hypothetical protein	-
ACM6AD_RS10050 (ACM6AD_10050)	map	2022587..2023345 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACM6AD_RS10055 (ACM6AD_10055)	-	2023876..2024862 (+)	987	WP_000999717.1	FUSC family protein	-
ACM6AD_RS10060 (ACM6AD_10060)	-	2025293..2025706 (-)	414	WP_001557448.1	hypothetical protein	-
ACM6AD_RS10065 (ACM6AD_10065)	-	2025735..2025845 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1098925 ACM6AD_RS10035 WP_001017131.1 2020228..2021271(-) (vraS) [Staphylococcus aureus strain AG21-0601]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1098925 ACM6AD_RS10035 WP_001017131.1 2020228..2021271(-) (vraS) [Staphylococcus aureus strain AG21-0601]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1