Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | ACM6AH_RS00285 | Genome accession | NZ_CP181115 |
| Coordinates | 62431..64059 (-) | Length | 542 a.a. |
| NCBI ID | WP_416152765.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain AG21-0608 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 57210..100935 | 62431..64059 | within | 0 |
| SCCmec | 44065..65430 | 62431..64059 | within | 0 |
Gene organization within MGE regions
Location: 44065..100935
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACM6AH_RS00185 (ACM6AH_00185) | mecA | 44065..46074 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| ACM6AH_RS00190 (ACM6AH_00190) | mecR1 | 46171..47928 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| ACM6AH_RS00195 (ACM6AH_00195) | mecI | 47928..48299 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| ACM6AH_RS00200 (ACM6AH_00200) | psm-mec | 48384..48452 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| ACM6AH_RS00205 (ACM6AH_00205) | - | 48786..49916 (+) | 1131 | WP_416152779.1 | ROK family protein | - |
| ACM6AH_RS00210 (ACM6AH_00210) | cstB | 50030..51364 (-) | 1335 | Protein_39 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ACM6AH_RS00215 (ACM6AH_00215) | - | 51397..52461 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| ACM6AH_RS00220 (ACM6AH_00220) | cstR | 52597..52857 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| ACM6AH_RS00225 (ACM6AH_00225) | - | 52857..53495 (+) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| ACM6AH_RS00230 (ACM6AH_00230) | - | 53840..54502 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| ACM6AH_RS00235 (ACM6AH_00235) | - | 54894..54953 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| ACM6AH_RS00240 (ACM6AH_00240) | erm(A) | 55036..55767 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| ACM6AH_RS00245 (ACM6AH_00245) | - | 55893..56675 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| ACM6AH_RS00250 (ACM6AH_00250) | - | 56826..57203 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| ACM6AH_RS00255 (ACM6AH_00255) | - | 57210..59102 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| ACM6AH_RS00260 (ACM6AH_00260) | - | 59099..60184 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| ACM6AH_RS00265 (ACM6AH_00265) | - | 60303..60620 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| ACM6AH_RS00270 (ACM6AH_00270) | - | 60641..61147 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| ACM6AH_RS00275 (ACM6AH_00275) | - | 61165..61476 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| ACM6AH_RS00280 (ACM6AH_00280) | - | 61563..61913 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ACM6AH_RS00285 (ACM6AH_00285) | ccrB | 62431..64059 (-) | 1629 | WP_416152765.1 | cassette chromosome recombinase CcrB | Machinery gene |
| ACM6AH_RS00290 (ACM6AH_00290) | ccrA | 64081..65430 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| ACM6AH_RS00295 (ACM6AH_00295) | cch1 | 65664..67457 (-) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| ACM6AH_RS00300 (ACM6AH_00300) | ssb | 67457..67753 (-) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| ACM6AH_RS00305 (ACM6AH_00305) | - | 67946..68992 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| ACM6AH_RS00310 (ACM6AH_00310) | - | 69243..70384 (-) | 1142 | Protein_59 | IS3-like element ISSau4 family transposase | - |
| ACM6AH_RS00315 (ACM6AH_00315) | - | 70554..70688 (+) | 135 | WP_001792216.1 | hypothetical protein | - |
| ACM6AH_RS00320 (ACM6AH_00320) | - | 70895..71830 (-) | 936 | Protein_61 | YfcC family protein | - |
| ACM6AH_RS00325 (ACM6AH_00325) | - | 72543..73238 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| ACM6AH_RS00330 (ACM6AH_00330) | - | 73213..75882 (-) | 2670 | WP_000446429.1 | sensor histidine kinase | - |
| ACM6AH_RS00335 (ACM6AH_00335) | kdpF | 76049..76129 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| ACM6AH_RS00340 (ACM6AH_00340) | kdpA | 76150..77826 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| ACM6AH_RS00345 (ACM6AH_00345) | - | 77845..79866 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| ACM6AH_RS00350 (ACM6AH_00350) | - | 79882..80439 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| ACM6AH_RS00355 (ACM6AH_00355) | - | 80984..81853 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| ACM6AH_RS00360 (ACM6AH_00360) | - | 81863..82759 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| ACM6AH_RS00365 (ACM6AH_00365) | - | 83878..84504 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| ACM6AH_RS00370 (ACM6AH_00370) | - | 84619..86127 (+) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| ACM6AH_RS00375 (ACM6AH_00375) | - | 86377..86511 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| ACM6AH_RS00380 (ACM6AH_00380) | - | 86475..86567 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| ACM6AH_RS00385 (ACM6AH_00385) | - | 86714..88459 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| ACM6AH_RS00390 (ACM6AH_00390) | - | 88557..88912 (-) | 356 | Protein_75 | tRNA-dihydrouridine synthase | - |
| ACM6AH_RS00395 (ACM6AH_00395) | - | 89217..89305 (-) | 89 | Protein_76 | hypothetical protein | - |
| ACM6AH_RS00400 (ACM6AH_00400) | - | 89403..90158 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| ACM6AH_RS00405 (ACM6AH_00405) | cstR | 90158..90418 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| ACM6AH_RS00410 (ACM6AH_00410) | cstA | 90555..91619 (+) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| ACM6AH_RS00415 (ACM6AH_00415) | cstB | 91650..92984 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ACM6AH_RS00420 (ACM6AH_00420) | sqr | 93003..94196 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| ACM6AH_RS00425 (ACM6AH_00425) | - | 94463..94677 (-) | 215 | Protein_82 | universal stress protein | - |
| ACM6AH_RS00430 (ACM6AH_00430) | - | 94863..95849 (-) | 987 | WP_000662022.1 | tRNA dihydrouridine synthase | - |
| ACM6AH_RS00435 (ACM6AH_00435) | - | 96158..96361 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| ACM6AH_RS00440 (ACM6AH_00440) | - | 96410..96706 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| ACM6AH_RS00445 (ACM6AH_00445) | - | 96914..97516 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| ACM6AH_RS00450 (ACM6AH_00450) | - | 97783..100935 (+) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62636.78 Da Isoelectric Point: 9.8600
>NTDB_id=1098504 ACM6AH_RS00285 WP_416152765.1 62431..64059(-) (ccrB) [Staphylococcus aureus strain AG21-0608]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPAIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPAIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=1098504 ACM6AH_RS00285 WP_416152765.1 62431..64059(-) (ccrB) [Staphylococcus aureus strain AG21-0608]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGCGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGCGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
99.815 |
100 |
0.998 |