Detailed information NTG1098461

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: ACM6AI_RS00290
• Genome accession: NZ_CP181113
• Coordinates: 64004..65353 (-)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain AG21-0609
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	44014..65353	64004..65353	within	0

Gene organization within MGE regions

Location: 44014..65353

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACM6AI_RS00185 (ACM6AI_00185)	mecA	44014..46023 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
ACM6AI_RS00190 (ACM6AI_00190)	mecR1	46120..47877 (+)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
ACM6AI_RS00195 (ACM6AI_00195)	mecI	47877..48248 (+)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
ACM6AI_RS00200 (ACM6AI_00200)	psm-mec	48333..48401 (-)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
ACM6AI_RS00205 (ACM6AI_00205)	-	48735..49865 (+)	1131	WP_010922808.1	ROK family transcriptional regulator	-
ACM6AI_RS00210 (ACM6AI_00210)	cstB	49979..51313 (-)	1335	Protein_39	persulfide dioxygenase-sulfurtransferase CstB	-
ACM6AI_RS00215 (ACM6AI_00215)	-	51346..52410 (-)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
ACM6AI_RS00220 (ACM6AI_00220)	cstR	52546..52805 (+)	260	Protein_41	persulfide-sensing transcriptional repressor CstR	-
ACM6AI_RS00225 (ACM6AI_00225)	-	52805..53443 (+)	639	Protein_42	sulfite exporter TauE/SafE family protein	-
ACM6AI_RS00230 (ACM6AI_00230)	-	53788..54450 (-)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
ACM6AI_RS00235 (ACM6AI_00235)	-	54842..54901 (+)	60	WP_010959190.1	erythromycin resistance leader peptide	-
ACM6AI_RS00240 (ACM6AI_00240)	erm(A)	54959..55690 (+)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
ACM6AI_RS00245 (ACM6AI_00245)	-	55816..56598 (-)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
ACM6AI_RS00250 (ACM6AI_00250)	-	56749..57126 (-)	378	WP_000361059.1	DUF6262 family protein	-
ACM6AI_RS00255 (ACM6AI_00255)	-	57133..59025 (-)	1893	WP_001557544.1	site-specific integrase	-
ACM6AI_RS00260 (ACM6AI_00260)	-	59022..60107 (-)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
ACM6AI_RS00265 (ACM6AI_00265)	-	60226..60543 (-)	318	WP_000659050.1	JAB domain-containing protein	-
ACM6AI_RS00270 (ACM6AI_00270)	-	60564..61070 (-)	507	WP_001092169.1	DUF1643 domain-containing protein	-
ACM6AI_RS00275 (ACM6AI_00275)	-	61088..61399 (-)	312	WP_000700853.1	DUF960 family protein	-
ACM6AI_RS00280 (ACM6AI_00280)	-	61486..61836 (-)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
ACM6AI_RS00285 (ACM6AI_00285)	ccrB	62354..63982 (-)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
ACM6AI_RS00290 (ACM6AI_00290)	ccrA	64004..65353 (-)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=1098461 ACM6AI_RS00290 WP_000815646.1 64004..65353(-) (ccrA) [Staphylococcus aureus strain AG21-0609]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=1098461 ACM6AI_RS00290 WP_000815646.1 64004..65353(-) (ccrA) [Staphylococcus aureus strain AG21-0609]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748