Detailed information NTG1098407

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACM6AK_RS10000
• Genome accession: NZ_CP181109
• Coordinates: 2021866..2022909 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain AG21-0611
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2016866..2027909

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACM6AK_RS09970 (ACM6AK_09970)	-	2017287..2018543 (-)	1257	WP_001795108.1	aminopeptidase	-
ACM6AK_RS09975 (ACM6AK_09975)	-	2018546..2018746 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACM6AK_RS09980 (ACM6AK_09980)	-	2018893..2019357 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACM6AK_RS09985 (ACM6AK_09985)	-	2019364..2019639 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACM6AK_RS09990 (ACM6AK_09990)	-	2019917..2021134 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACM6AK_RS09995 (ACM6AK_09995)	vraR	2021247..2021876 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACM6AK_RS10000 (ACM6AK_10000)	vraS	2021866..2022909 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACM6AK_RS10005 (ACM6AK_10005)	liaF	2022906..2023607 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACM6AK_RS10010 (ACM6AK_10010)	-	2023622..2024008 (-)	387	WP_001110179.1	hypothetical protein	-
ACM6AK_RS10015 (ACM6AK_10015)	map	2024225..2024983 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACM6AK_RS10020 (ACM6AK_10020)	-	2025514..2026500 (+)	987	WP_000999717.1	FUSC family protein	-
ACM6AK_RS10025 (ACM6AK_10025)	-	2026931..2027344 (-)	414	WP_001557448.1	hypothetical protein	-
ACM6AK_RS10030 (ACM6AK_10030)	-	2027373..2027483 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1098407 ACM6AK_RS10000 WP_001017131.1 2021866..2022909(-) (vraS) [Staphylococcus aureus strain AG21-0611]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1098407 ACM6AK_RS10000 WP_001017131.1 2021866..2022909(-) (vraS) [Staphylococcus aureus strain AG21-0611]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1