Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | ACM6AN_RS00290 | Genome accession | NZ_CP181102 |
| Coordinates | 64050..65399 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain AG21-0614 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 57179..100941 | 64050..65399 | within | 0 |
| SCCmec | 44034..65399 | 64050..65399 | within | 0 |
Gene organization within MGE regions
Location: 44034..100941
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACM6AN_RS00185 (ACM6AN_00185) | mecA | 44034..46043 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| ACM6AN_RS00190 (ACM6AN_00190) | mecR1 | 46140..47897 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| ACM6AN_RS00195 (ACM6AN_00195) | mecI | 47897..48268 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| ACM6AN_RS00200 (ACM6AN_00200) | psm-mec | 48353..48421 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| ACM6AN_RS00205 (ACM6AN_00205) | - | 48755..49885 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| ACM6AN_RS00210 (ACM6AN_00210) | cstB | 49999..51333 (-) | 1335 | Protein_39 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ACM6AN_RS00215 (ACM6AN_00215) | - | 51366..52430 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| ACM6AN_RS00220 (ACM6AN_00220) | cstR | 52566..52826 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| ACM6AN_RS00225 (ACM6AN_00225) | - | 52826..53464 (+) | 639 | Protein_42 | sulfite exporter TauE/SafE family protein | - |
| ACM6AN_RS00230 (ACM6AN_00230) | - | 53809..54471 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| ACM6AN_RS00235 (ACM6AN_00235) | - | 54863..54922 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| ACM6AN_RS00240 (ACM6AN_00240) | erm(A) | 55005..55736 (+) | 732 | WP_416152538.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| ACM6AN_RS00245 (ACM6AN_00245) | ant(9) | 55862..56644 (-) | 783 | WP_086031901.1 | aminoglycoside nucleotidyltransferase ANT(9) | - |
| ACM6AN_RS00250 (ACM6AN_00250) | - | 56795..57172 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| ACM6AN_RS00255 (ACM6AN_00255) | - | 57179..59071 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| ACM6AN_RS00260 (ACM6AN_00260) | - | 59068..60153 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| ACM6AN_RS00265 (ACM6AN_00265) | - | 60272..60589 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| ACM6AN_RS00270 (ACM6AN_00270) | - | 60610..61116 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| ACM6AN_RS00275 (ACM6AN_00275) | - | 61134..61445 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| ACM6AN_RS00280 (ACM6AN_00280) | - | 61532..61882 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| ACM6AN_RS00285 (ACM6AN_00285) | ccrB | 62400..64028 (-) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| ACM6AN_RS00290 (ACM6AN_00290) | ccrA | 64050..65399 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| ACM6AN_RS00295 (ACM6AN_00295) | cch1 | 65633..67426 (-) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| ACM6AN_RS00300 (ACM6AN_00300) | ssb | 67426..67722 (-) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| ACM6AN_RS00305 (ACM6AN_00305) | - | 67915..68961 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| ACM6AN_RS00310 (ACM6AN_00310) | - | 69212..70353 (-) | 1142 | Protein_59 | IS3-like element ISSau4 family transposase | - |
| ACM6AN_RS00315 (ACM6AN_00315) | - | 70901..71836 (-) | 936 | Protein_60 | YfcC family protein | - |
| ACM6AN_RS00320 (ACM6AN_00320) | - | 72549..73244 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| ACM6AN_RS00325 (ACM6AN_00325) | - | 73219..75888 (-) | 2670 | WP_416152539.1 | ATP-binding protein | - |
| ACM6AN_RS00330 (ACM6AN_00330) | kdpF | 76055..76135 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| ACM6AN_RS00335 (ACM6AN_00335) | kdpA | 76156..77832 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| ACM6AN_RS00340 (ACM6AN_00340) | - | 77851..79872 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| ACM6AN_RS00345 (ACM6AN_00345) | - | 79888..80445 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| ACM6AN_RS00350 (ACM6AN_00350) | - | 80990..81859 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| ACM6AN_RS00355 (ACM6AN_00355) | - | 81869..82765 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| ACM6AN_RS00360 (ACM6AN_00360) | - | 83884..84510 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| ACM6AN_RS00365 (ACM6AN_00365) | - | 84625..86133 (+) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| ACM6AN_RS00370 (ACM6AN_00370) | - | 86383..86517 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| ACM6AN_RS00375 (ACM6AN_00375) | - | 86481..86573 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| ACM6AN_RS00380 (ACM6AN_00380) | - | 86720..88465 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| ACM6AN_RS00385 (ACM6AN_00385) | - | 88563..88918 (-) | 356 | Protein_74 | tRNA-dihydrouridine synthase | - |
| ACM6AN_RS00390 (ACM6AN_00390) | - | 89223..89311 (-) | 89 | Protein_75 | hypothetical protein | - |
| ACM6AN_RS00395 (ACM6AN_00395) | - | 89409..90164 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| ACM6AN_RS00400 (ACM6AN_00400) | cstR | 90164..90424 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| ACM6AN_RS00405 (ACM6AN_00405) | cstA | 90561..91625 (+) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| ACM6AN_RS00410 (ACM6AN_00410) | cstB | 91656..92990 (+) | 1335 | WP_086032561.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| ACM6AN_RS00415 (ACM6AN_00415) | sqr | 93009..94202 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| ACM6AN_RS00420 (ACM6AN_00420) | - | 94469..94683 (-) | 215 | Protein_81 | universal stress protein | - |
| ACM6AN_RS00425 (ACM6AN_00425) | - | 94869..95855 (-) | 987 | WP_000662022.1 | tRNA dihydrouridine synthase | - |
| ACM6AN_RS00430 (ACM6AN_00430) | - | 96164..96367 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| ACM6AN_RS00435 (ACM6AN_00435) | - | 96416..96712 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| ACM6AN_RS00440 (ACM6AN_00440) | - | 96920..97522 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| ACM6AN_RS00445 (ACM6AN_00445) | - | 97789..100941 (+) | 3153 | WP_086031877.1 | DEAD/DEAH box helicase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=1098246 ACM6AN_RS00290 WP_000815646.1 64050..65399(-) (ccrA) [Staphylococcus aureus strain AG21-0614]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=1098246 ACM6AN_RS00290 WP_000815646.1 64050..65399(-) (ccrA) [Staphylococcus aureus strain AG21-0614]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |