Detailed information NTG0109798

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: ABXG87_RS05385
• Genome accession: NZ_AP031488
• Coordinates: 1182259..1183599 (-)
• Length: 446 a.a.
• NCBI ID: WP_002885062.1
• Uniprot ID: A0A0F3HCD0
• Organism: Streptococcus salivarius strain NBRC 13956
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1177259..1188599

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABXG87_RS05355 (Ssa13956_10010)	-	1177409..1178275 (-)	867	WP_004182606.1	GNAT family N-acetyltransferase	-
ABXG87_RS05360 (Ssa13956_10020)	yidA	1178454..1179260 (+)	807	WP_004182607.1	sugar-phosphatase	-
ABXG87_RS05365 (Ssa13956_10030)	-	1179260..1180474 (+)	1215	WP_004182608.1	aminoacyltransferase	-
ABXG87_RS05370	-	1180576..1180852 (-)	277	Protein_1004	ISL3 family transposase	-
ABXG87_RS05375 (Ssa13956_10040)	-	1181023..1181382 (-)	360	WP_045769141.1	YbaN family protein	-
ABXG87_RS05380 (Ssa13956_10050)	vicX	1181441..1182253 (-)	813	WP_013990680.1	MBL fold metallo-hydrolase	Regulator
ABXG87_RS05385 (Ssa13956_10060)	vicK	1182259..1183599 (-)	1341	WP_002885062.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ABXG87_RS05390 (Ssa13956_10070)	vicR	1183592..1184299 (-)	708	WP_002884978.1	response regulator YycF	Regulator
ABXG87_RS05395 (Ssa13956_10080)	-	1184584..1185351 (+)	768	WP_038675884.1	amino acid ABC transporter ATP-binding protein	-
ABXG87_RS05400 (Ssa13956_10090)	-	1185361..1186194 (+)	834	WP_013990682.1	transporter substrate-binding domain-containing protein	-
ABXG87_RS05405 (Ssa13956_10100)	-	1186212..1186910 (+)	699	WP_002886251.1	amino acid ABC transporter permease	-
ABXG87_RS05410 (Ssa13956_10110)	-	1186922..1187572 (+)	651	WP_045769140.1	amino acid ABC transporter permease	-
ABXG87_RS05415 (Ssa13956_10120)	-	1187760..1188527 (+)	768	WP_002885036.1	amino acid ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 446 a.a.
• Molecular weight: 50945.21 Da
• Isoelectric Point: 5.1606

>NTDB_id=109798 ABXG87_RS05385 WP_002885062.1 1182259..1183599(-) (vicK) [Streptococcus salivarius strain NBRC 13956]
MTSIGLNITSFELALLFTLLFVAFYFIFLAYRDYRRVKNIRKLTKRVKSLMAGNYNEELRLKGDPELLELADSLNDLSDV
FRLTHENLAQEKNRLSSVLSYMSDGVIATNRRGQITMINSTAQRLLNLDYETATQMSILDLLDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALDE
EIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLDVEMTNFTAFMTYILNRFDQIKSQETNTGKTYEIIRDYPVNSI
WVEIDTDKMTQVVDNILNNAIKYSPDGGKITVSMKTTDSQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAMMVDEWEM

Nucleotide

• Length: 1341 bp

>NTDB_id=109798 ABXG87_RS05385 WP_002885062.1 1182259..1183599(-) (vicK) [Streptococcus salivarius strain NBRC 13956]
ATGACTAGTATTGGCTTAAACATCACAAGCTTTGAACTAGCCTTACTCTTTACGCTCCTCTTTGTGGCTTTCTACTTTAT
TTTTCTTGCATATCGTGATTATCGACGAGTCAAAAATATTCGAAAGTTGACCAAGAGGGTCAAGTCCTTAATGGCAGGTA
ACTATAACGAGGAGTTACGCTTAAAGGGTGATCCAGAGCTTTTAGAGCTAGCTGACAGCTTGAATGATTTATCGGATGTC
TTTCGTTTGACGCATGAAAATCTAGCCCAGGAAAAAAACCGCTTATCATCAGTCCTTTCTTACATGAGTGATGGGGTTAT
TGCGACAAATCGTCGTGGTCAGATTACCATGATTAATAGCACAGCTCAGCGTTTGTTGAATCTAGATTATGAAACAGCGA
CACAGATGTCCATTTTAGATTTATTAGATGGCGAAAATCCCTATACTTATAGTGAATTGCTCTCTAAGACTCCTGAAATT
CATTTGTCACGTCGAGATGCCAACGATGAGTTTGTGACCTTACGTGTTAATTTTGCCCTTATTCGTAAAGAATCAGGTTT
TATCTCAGGTTTGGTTGCCGTTCTTCATGATGCTACTGAGCAGGAAAAAGAAGAGCGTGAACGCCGACTTTTCGTCTCAA
ACGTTAGTCATGAGTTGCGTACACCTTTGACTTCTGTAAAATCCTATCTGGAGGCACTTGATGATGGAGCTCTCGATGAA
GAGATTGCTCCTAACTTTATCAAAGTTTCTTTGGATGAGACCAATCGTATGATGCGAATGATTTCTGACCTCTTGGCACT
GTCTCGTATTGACAATAAGAGTACCCAACTTGACGTTGAAATGACTAATTTCACAGCCTTCATGACCTATATCTTGAATC
GTTTTGATCAGATTAAGAGTCAAGAAACCAATACAGGTAAAACTTACGAAATCATTCGCGATTATCCTGTAAACTCAATT
TGGGTGGAGATTGATACAGATAAGATGACCCAGGTCGTGGATAATATTCTTAATAATGCCATCAAGTATTCGCCTGATGG
TGGTAAGATTACAGTGTCTATGAAGACAACTGATTCGCAGTTGATTGTTTCTATTTCTGACCAAGGTTTGGGTATTCCTA
AGAAAGATTTGCCTTTGATTTTCGACCGTTTTTACCGTGTTGATAAGGCAAGAAGTCGTGCCCAGGGTGGAACTGGTCTA
GGCTTGTCTATTGCAAAAGAAATTATTAAACAACATAAGGGCTTTATTTGGGCTAAGAGTGAGTATGGTAAGGGTTCAAC
TTTTACAATTGTGCTTCCATATGACAAGGATGCCATGATGGTTGATGAATGGGAGATGTAG

Domains

Predicted by InterproScan.

• PAS fold (PAS) (94-197)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (325-435)

• His Kinase A (phospho-acceptor) domain (HisKA) (208-272)

3D structure

• AlphaFold DB: A0A0F3HCD0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	73.671	92.825	0.684
micB	Streptococcus pneumoniae Cp1015	67.667	97.085	0.657