Detailed information NTG1096265

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACLKMS_RS04305
• Genome accession: NZ_CP180533
• Coordinates: 921965..923011 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain BP21
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 916965..928011

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLKMS_RS04280 (ACLKMS_04280)	isaB	918106..918642 (+)	537	WP_415918760.1	immunodominant staphylococcal antigen IsaB family protein	-
ACLKMS_RS04285 (ACLKMS_04285)	-	918793..919779 (-)	987	WP_002457091.1	FUSC family protein	-
ACLKMS_RS04290 (ACLKMS_04290)	map	919953..920708 (+)	756	WP_151520931.1	type I methionyl aminopeptidase	-
ACLKMS_RS04295 (ACLKMS_04295)	-	920866..921252 (+)	387	WP_001830382.1	hypothetical protein	-
ACLKMS_RS04300 (ACLKMS_04300)	liaF	921267..921968 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
ACLKMS_RS04305 (ACLKMS_04305)	vraS	921965..923011 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
ACLKMS_RS04310 (ACLKMS_04310)	vraR	923001..923630 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
ACLKMS_RS04315 (ACLKMS_04315)	-	923687..924865 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
ACLKMS_RS04320 (ACLKMS_04320)	-	925272..925556 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
ACLKMS_RS04325 (ACLKMS_04325)	-	925564..926028 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
ACLKMS_RS04330 (ACLKMS_04330)	-	926169..926384 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
ACLKMS_RS04335 (ACLKMS_04335)	-	926386..927627 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=1096265 ACLKMS_RS04305 WP_001830374.1 921965..923011(+) (vraS) [Staphylococcus epidermidis strain BP21]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=1096265 ACLKMS_RS04305 WP_001830374.1 921965..923011(+) (vraS) [Staphylococcus epidermidis strain BP21]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92