Detailed information NTG1094323

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACMUKE_RS04335
• Genome accession: NZ_CP180178
• Coordinates: 932880..933926 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 1457c
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 927880..938926

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACMUKE_RS04310 (ACMUKE_04310)	isaB	929021..929557 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
ACMUKE_RS04315 (ACMUKE_04315)	-	929708..930694 (-)	987	WP_001830388.1	FUSC family protein	-
ACMUKE_RS04320 (ACMUKE_04320)	map	930868..931623 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
ACMUKE_RS04325 (ACMUKE_04325)	-	931781..932167 (+)	387	WP_001830382.1	hypothetical protein	-
ACMUKE_RS04330 (ACMUKE_04330)	liaF	932182..932883 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
ACMUKE_RS04335 (ACMUKE_04335)	vraS	932880..933926 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
ACMUKE_RS04340 (ACMUKE_04340)	vraR	933916..934545 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
ACMUKE_RS04345 (ACMUKE_04345)	-	934602..935780 (-)	1179	WP_002485151.1	YihY/virulence factor BrkB family protein	-
ACMUKE_RS04350 (ACMUKE_04350)	-	936187..936471 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
ACMUKE_RS04355 (ACMUKE_04355)	-	936479..936943 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
ACMUKE_RS04360 (ACMUKE_04360)	-	937084..937299 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
ACMUKE_RS04365 (ACMUKE_04365)	-	937301..938542 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=1094323 ACMUKE_RS04335 WP_001830374.1 932880..933926(+) (vraS) [Staphylococcus epidermidis strain 1457c]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=1094323 ACMUKE_RS04335 WP_001830374.1 932880..933926(+) (vraS) [Staphylococcus epidermidis strain 1457c]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92