Detailed information NTG1094287

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACMUKD_RS04440
• Genome accession: NZ_CP180177
• Coordinates: 947699..948745 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 1457LA
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 942699..953745

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACMUKD_RS04415 (ACMUKD_04415)	isaB	943840..944376 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
ACMUKD_RS04420 (ACMUKD_04420)	-	944527..945513 (-)	987	WP_001830388.1	FUSC family protein	-
ACMUKD_RS04425 (ACMUKD_04425)	map	945687..946442 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
ACMUKD_RS04430 (ACMUKD_04430)	-	946600..946986 (+)	387	WP_001830382.1	hypothetical protein	-
ACMUKD_RS04435 (ACMUKD_04435)	liaF	947001..947702 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
ACMUKD_RS04440 (ACMUKD_04440)	vraS	947699..948745 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
ACMUKD_RS04445 (ACMUKD_04445)	vraR	948735..949364 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
ACMUKD_RS04450 (ACMUKD_04450)	-	949421..950599 (-)	1179	WP_002485151.1	YihY/virulence factor BrkB family protein	-
ACMUKD_RS04455 (ACMUKD_04455)	-	951006..951290 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
ACMUKD_RS04460 (ACMUKD_04460)	-	951298..951762 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
ACMUKD_RS04465 (ACMUKD_04465)	-	951903..952118 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
ACMUKD_RS04470 (ACMUKD_04470)	-	952120..953361 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=1094287 ACMUKD_RS04440 WP_001830374.1 947699..948745(+) (vraS) [Staphylococcus epidermidis strain 1457LA]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=1094287 ACMUKD_RS04440 WP_001830374.1 947699..948745(+) (vraS) [Staphylococcus epidermidis strain 1457LA]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92