Detailed information
Bioinformatically predicted
Overview
| Name | comGA | Type | Machinery gene |
| Locus tag | ACMGE7_RS06765 | Genome accession | NZ_CP179731 |
| Coordinates | 1292187..1293155 (-) | Length | 322 a.a. |
| NCBI ID | WP_414046289.1 | Uniprot ID | - |
| Organism | Macrococcus sp. 18KM245 | ||
| Function | dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1239635..1299957 | 1292187..1293155 | within | 0 |
Gene organization within MGE regions
Location: 1239635..1299957
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACMGE7_RS06445 (ACMGE7_06445) | xerD | 1239635..1240522 (-) | 888 | WP_414046348.1 | site-specific tyrosine recombinase XerD | - |
| ACMGE7_RS06450 (ACMGE7_06450) | - | 1240619..1241098 (-) | 480 | WP_414046347.1 | Fur family transcriptional regulator | - |
| ACMGE7_RS06455 (ACMGE7_06455) | - | 1241189..1241734 (-) | 546 | WP_414046346.1 | NUDIX hydrolase | - |
| ACMGE7_RS06460 (ACMGE7_06460) | - | 1241798..1242715 (+) | 918 | WP_414046345.1 | aldo/keto reductase | - |
| ACMGE7_RS06465 (ACMGE7_06465) | - | 1242712..1243701 (+) | 990 | WP_414046344.1 | alpha/beta hydrolase | - |
| ACMGE7_RS06470 (ACMGE7_06470) | - | 1243717..1244493 (-) | 777 | WP_414046947.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| ACMGE7_RS06475 (ACMGE7_06475) | proC | 1244575..1245378 (+) | 804 | WP_414046342.1 | pyrroline-5-carboxylate reductase | - |
| ACMGE7_RS06480 (ACMGE7_06480) | rnz | 1245450..1246370 (-) | 921 | WP_414046341.1 | ribonuclease Z | - |
| ACMGE7_RS06485 (ACMGE7_06485) | zwf | 1246479..1247957 (+) | 1479 | WP_414046340.1 | glucose-6-phosphate dehydrogenase | - |
| ACMGE7_RS06490 (ACMGE7_06490) | - | 1248030..1248659 (+) | 630 | WP_414046948.1 | hypothetical protein | - |
| ACMGE7_RS06495 (ACMGE7_06495) | - | 1248687..1249523 (+) | 837 | WP_414046338.1 | helix-turn-helix domain-containing protein | - |
| ACMGE7_RS06500 (ACMGE7_06500) | - | 1249650..1251002 (-) | 1353 | WP_414046854.1 | IS1182 family transposase | - |
| ACMGE7_RS06505 (ACMGE7_06505) | gndA | 1251127..1252530 (-) | 1404 | WP_414046337.1 | NADP-dependent phosphogluconate dehydrogenase | - |
| ACMGE7_RS06510 (ACMGE7_06510) | - | 1252591..1253694 (-) | 1104 | WP_414046336.1 | M20/M25/M40 family metallo-hydrolase | - |
| ACMGE7_RS06515 (ACMGE7_06515) | - | 1253943..1254911 (-) | 969 | WP_414046335.1 | aromatic acid exporter family protein | - |
| ACMGE7_RS06520 (ACMGE7_06520) | - | 1254919..1255356 (-) | 438 | WP_414046334.1 | BrxA/BrxB family bacilliredoxin | - |
| ACMGE7_RS06525 (ACMGE7_06525) | - | 1255653..1256135 (+) | 483 | WP_414046333.1 | GNAT family N-acetyltransferase | - |
| ACMGE7_RS06530 (ACMGE7_06530) | - | 1256132..1256614 (+) | 483 | WP_414046332.1 | CHAP domain-containing protein | - |
| ACMGE7_RS06535 (ACMGE7_06535) | - | 1256682..1256894 (-) | 213 | WP_414046331.1 | hypothetical protein | - |
| ACMGE7_RS06540 (ACMGE7_06540) | - | 1256908..1257822 (-) | 915 | WP_414046330.1 | hypothetical protein | - |
| ACMGE7_RS06545 (ACMGE7_06545) | - | 1257976..1258647 (-) | 672 | WP_414046329.1 | type 1 glutamine amidotransferase domain-containing protein | - |
| ACMGE7_RS06550 (ACMGE7_06550) | - | 1259079..1260365 (+) | 1287 | WP_414046328.1 | RtcB family protein | - |
| ACMGE7_RS06555 (ACMGE7_06555) | - | 1260385..1260630 (+) | 246 | WP_414046853.1 | hypothetical protein | - |
| ACMGE7_RS06560 (ACMGE7_06560) | - | 1260648..1261277 (-) | 630 | WP_414046949.1 | FusB/FusC family EF-G-binding protein | - |
| ACMGE7_RS06565 (ACMGE7_06565) | - | 1261504..1261890 (-) | 387 | WP_414046326.1 | hypothetical protein | - |
| ACMGE7_RS06570 (ACMGE7_06570) | - | 1261961..1262920 (+) | 960 | WP_414046325.1 | IS30 family transposase | - |
| ACMGE7_RS06575 (ACMGE7_06575) | - | 1263007..1263756 (-) | 750 | WP_414046324.1 | nucleoside phosphorylase | - |
| ACMGE7_RS06580 (ACMGE7_06580) | - | 1263934..1264245 (+) | 312 | WP_414046323.1 | hypothetical protein | - |
| ACMGE7_RS06585 (ACMGE7_06585) | - | 1264259..1264588 (+) | 330 | WP_414046322.1 | hypothetical protein | - |
| ACMGE7_RS06590 (ACMGE7_06590) | - | 1264595..1264780 (+) | 186 | WP_233680313.1 | helix-turn-helix transcriptional regulator | - |
| ACMGE7_RS06595 (ACMGE7_06595) | - | 1264809..1265315 (-) | 507 | WP_414046321.1 | GrpB family protein | - |
| ACMGE7_RS06600 (ACMGE7_06600) | - | 1265492..1265923 (+) | 432 | WP_414046320.1 | LytTR family transcriptional regulator DNA-binding domain-containing protein | - |
| ACMGE7_RS06605 (ACMGE7_06605) | - | 1266472..1266993 (-) | 522 | WP_414046319.1 | tunicamycin resistance protein | - |
| ACMGE7_RS06610 (ACMGE7_06610) | - | 1267080..1267583 (-) | 504 | WP_414046318.1 | DJ-1/PfpI family protein | - |
| ACMGE7_RS06615 (ACMGE7_06615) | - | 1267669..1267872 (-) | 204 | WP_414046317.1 | hypothetical protein | - |
| ACMGE7_RS06620 (ACMGE7_06620) | - | 1267933..1269033 (-) | 1101 | WP_414046316.1 | Glu/Leu/Phe/Val dehydrogenase dimerization domain-containing protein | - |
| ACMGE7_RS06625 (ACMGE7_06625) | - | 1269351..1269587 (+) | 237 | WP_414046315.1 | DUF2627 domain-containing protein | - |
| ACMGE7_RS06630 (ACMGE7_06630) | - | 1269630..1270361 (-) | 732 | WP_414046314.1 | glycerophosphodiester phosphodiesterase family protein | - |
| ACMGE7_RS06635 (ACMGE7_06635) | - | 1270354..1271046 (-) | 693 | WP_414046313.1 | response regulator | - |
| ACMGE7_RS06640 (ACMGE7_06640) | recN | 1271064..1272731 (-) | 1668 | WP_414046312.1 | DNA repair protein RecN | - |
| ACMGE7_RS06645 (ACMGE7_06645) | ahrC | 1272745..1273197 (-) | 453 | WP_414046311.1 | transcriptional regulator AhrC/ArgR | - |
| ACMGE7_RS06650 (ACMGE7_06650) | - | 1273293..1274123 (-) | 831 | WP_414046310.1 | TlyA family RNA methyltransferase | - |
| ACMGE7_RS06655 (ACMGE7_06655) | dxs | 1274110..1275996 (-) | 1887 | WP_414046309.1 | 1-deoxy-D-xylulose-5-phosphate synthase | - |
| ACMGE7_RS06660 (ACMGE7_06660) | - | 1276092..1276952 (-) | 861 | WP_414046308.1 | polyprenyl synthetase family protein | - |
| ACMGE7_RS06665 (ACMGE7_06665) | xseB | 1276945..1277139 (-) | 195 | WP_414046307.1 | exodeoxyribonuclease VII small subunit | - |
| ACMGE7_RS06670 (ACMGE7_06670) | xseA | 1277142..1278479 (-) | 1338 | WP_414046950.1 | exodeoxyribonuclease VII large subunit | - |
| ACMGE7_RS06675 (ACMGE7_06675) | nusB | 1278487..1278879 (-) | 393 | WP_414046305.1 | transcription antitermination factor NusB | - |
| ACMGE7_RS06680 (ACMGE7_06680) | - | 1278924..1279271 (-) | 348 | WP_414046304.1 | Asp23/Gls24 family envelope stress response protein | - |
| ACMGE7_RS06685 (ACMGE7_06685) | accC | 1279360..1280706 (-) | 1347 | WP_414046951.1 | acetyl-CoA carboxylase biotin carboxylase subunit | - |
| ACMGE7_RS06690 (ACMGE7_06690) | accB | 1280709..1281164 (-) | 456 | WP_414046302.1 | acetyl-CoA carboxylase biotin carboxyl carrier protein | - |
| ACMGE7_RS06695 (ACMGE7_06695) | efp | 1281280..1281837 (-) | 558 | WP_096076375.1 | elongation factor P | - |
| ACMGE7_RS06700 (ACMGE7_06700) | - | 1281863..1282918 (-) | 1056 | WP_414046301.1 | M24 family metallopeptidase | - |
| ACMGE7_RS06705 (ACMGE7_06705) | - | 1283010..1283600 (+) | 591 | WP_414046300.1 | DUF6376 family protein | - |
| ACMGE7_RS06710 (ACMGE7_06710) | - | 1283655..1284497 (-) | 843 | WP_414046299.1 | biotin/lipoate A/B protein ligase family protein | - |
| ACMGE7_RS06715 (ACMGE7_06715) | - | 1284605..1284988 (+) | 384 | WP_414046298.1 | rhodanese-like domain-containing protein | - |
| ACMGE7_RS06720 (ACMGE7_06720) | gcvPB | 1285033..1286502 (-) | 1470 | WP_414046297.1 | aminomethyl-transferring glycine dehydrogenase subunit GcvPB | - |
| ACMGE7_RS06725 (ACMGE7_06725) | gcvPA | 1286495..1287838 (-) | 1344 | WP_414046296.1 | aminomethyl-transferring glycine dehydrogenase subunit GcvPA | - |
| ACMGE7_RS06730 (ACMGE7_06730) | gcvT | 1287851..1288936 (-) | 1086 | WP_414046784.1 | glycine cleavage system aminomethyltransferase GcvT | - |
| ACMGE7_RS06735 (ACMGE7_06735) | - | 1289070..1289576 (-) | 507 | WP_414046295.1 | shikimate kinase | - |
| ACMGE7_RS06740 (ACMGE7_06740) | comGF | 1289757..1290188 (-) | 432 | WP_414046294.1 | competence type IV pilus minor pilin ComGF | - |
| ACMGE7_RS06745 (ACMGE7_06745) | - | 1290151..1290396 (-) | 246 | WP_414046952.1 | hypothetical protein | - |
| ACMGE7_RS06750 (ACMGE7_06750) | - | 1290383..1290835 (-) | 453 | WP_414046852.1 | hypothetical protein | - |
| ACMGE7_RS06755 (ACMGE7_06755) | comGC | 1290801..1291151 (-) | 351 | WP_414046291.1 | competence type IV pilus major pilin ComGC | Machinery gene |
| ACMGE7_RS06760 (ACMGE7_06760) | comGB | 1291163..1292200 (-) | 1038 | WP_414046290.1 | competence type IV pilus assembly protein ComGB | - |
| ACMGE7_RS06765 (ACMGE7_06765) | comGA | 1292187..1293155 (-) | 969 | WP_414046289.1 | competence type IV pilus ATPase ComGA | Machinery gene |
| ACMGE7_RS06770 (ACMGE7_06770) | - | 1293368..1293616 (+) | 249 | WP_233680344.1 | DUF2626 domain-containing protein | - |
| ACMGE7_RS06775 (ACMGE7_06775) | - | 1293652..1294281 (-) | 630 | WP_414046288.1 | MBL fold metallo-hydrolase | - |
| ACMGE7_RS06780 (ACMGE7_06780) | - | 1294374..1294613 (+) | 240 | WP_414046287.1 | DUF2759 domain-containing protein | - |
| ACMGE7_RS06785 (ACMGE7_06785) | - | 1294647..1294958 (-) | 312 | WP_414046286.1 | MTH1187 family thiamine-binding protein | - |
| ACMGE7_RS06790 (ACMGE7_06790) | - | 1294958..1295929 (-) | 972 | WP_414046285.1 | ROK family glucokinase | - |
| ACMGE7_RS06795 (ACMGE7_06795) | - | 1295926..1296117 (-) | 192 | WP_414046284.1 | YqgQ family protein | - |
| ACMGE7_RS06800 (ACMGE7_06800) | - | 1296122..1297546 (-) | 1425 | WP_414046283.1 | rhomboid family intramembrane serine protease | - |
| ACMGE7_RS06805 (ACMGE7_06805) | - | 1297543..1298109 (-) | 567 | WP_414046282.1 | 5-formyltetrahydrofolate cyclo-ligase | - |
| ACMGE7_RS06810 (ACMGE7_06810) | rpmG | 1298198..1298347 (-) | 150 | WP_096076353.1 | 50S ribosomal protein L33 | - |
| ACMGE7_RS06815 (ACMGE7_06815) | phoU | 1298424..1299065 (-) | 642 | WP_414046281.1 | phosphate signaling complex protein PhoU | - |
| ACMGE7_RS06820 (ACMGE7_06820) | pstB | 1299070..1299957 (-) | 888 | WP_414046953.1 | phosphate ABC transporter ATP-binding protein PstB | - |
Sequence
Protein
Download Length: 322 a.a. Molecular weight: 36322.67 Da Isoelectric Point: 6.6856
>NTDB_id=1093020 ACMGE7_RS06765 WP_414046289.1 1292187..1293155(-) (comGA) [Macrococcus sp. 18KM245]
MEKLFTSILKDAILQQASDVHFIPSQKSVLIKLRIHGDMHDYDKIAINQFEKLLSYLKFITNLDVSEKNKAQSGTLNFDL
NAIHYNVRASTLPHSVGHEACVLRIIPTNFNEKADIEDDLLHLMHKGSGLILISGPTGSGKSTLMYHLLQYAVANLSKQV
ISIEDPVEQRIEGMIQINVNAKGNITYQNSLKAILRCDPDIIMIGEIRDADTAKNVINASLSGHLVLSTLHANSCLGAIH
RLMEMGISKVELEQSVERIINQRLVNTCSGRRRVYEQLNKSECRNYLSDQSLDSYLPINNQLNKMLDNNEITLMEHERYV
TE
MEKLFTSILKDAILQQASDVHFIPSQKSVLIKLRIHGDMHDYDKIAINQFEKLLSYLKFITNLDVSEKNKAQSGTLNFDL
NAIHYNVRASTLPHSVGHEACVLRIIPTNFNEKADIEDDLLHLMHKGSGLILISGPTGSGKSTLMYHLLQYAVANLSKQV
ISIEDPVEQRIEGMIQINVNAKGNITYQNSLKAILRCDPDIIMIGEIRDADTAKNVINASLSGHLVLSTLHANSCLGAIH
RLMEMGISKVELEQSVERIINQRLVNTCSGRRRVYEQLNKSECRNYLSDQSLDSYLPINNQLNKMLDNNEITLMEHERYV
TE
Nucleotide
Download Length: 969 bp
>NTDB_id=1093020 ACMGE7_RS06765 WP_414046289.1 1292187..1293155(-) (comGA) [Macrococcus sp. 18KM245]
ATGGAAAAACTATTTACTTCAATATTAAAAGATGCAATATTACAACAAGCCTCAGATGTTCACTTTATACCCAGTCAAAA
GAGTGTATTAATCAAATTACGAATCCATGGTGATATGCATGATTATGACAAAATAGCTATCAATCAATTTGAAAAATTAT
TGTCTTATCTAAAGTTTATCACCAACCTTGATGTTTCTGAAAAAAATAAAGCACAAAGCGGAACCCTGAATTTTGATTTA
AATGCTATTCATTATAATGTGCGTGCTTCTACATTACCTCATTCGGTAGGTCATGAAGCATGTGTTTTAAGGATAATTCC
TACCAATTTTAATGAAAAAGCAGATATTGAAGATGATTTATTACATTTAATGCATAAAGGTAGTGGTCTGATTTTAATAA
GTGGACCAACGGGTAGTGGTAAGAGTACATTAATGTATCATCTGCTTCAATATGCAGTTGCAAATTTAAGTAAACAAGTG
ATATCGATAGAGGATCCTGTTGAACAAAGGATTGAAGGTATGATACAAATTAACGTCAACGCAAAAGGGAATATCACCTA
TCAGAATTCACTCAAAGCAATATTAAGATGTGATCCGGATATTATTATGATTGGCGAAATACGGGACGCAGATACCGCTA
AAAATGTAATCAATGCGAGTTTAAGTGGCCATCTAGTATTATCGACACTACATGCAAATTCCTGTTTAGGGGCAATACAT
CGATTGATGGAAATGGGCATCTCAAAAGTTGAACTTGAACAGAGTGTTGAAAGAATAATAAATCAAAGATTAGTAAACAC
TTGTTCTGGTAGAAGACGTGTTTACGAACAACTAAATAAGAGTGAATGTCGCAATTATTTATCTGATCAGTCATTAGATT
CATATCTCCCTATTAATAATCAATTAAATAAGATGCTTGATAATAATGAGATAACTTTAATGGAGCATGAACGTTATGTT
ACTGAGTAG
ATGGAAAAACTATTTACTTCAATATTAAAAGATGCAATATTACAACAAGCCTCAGATGTTCACTTTATACCCAGTCAAAA
GAGTGTATTAATCAAATTACGAATCCATGGTGATATGCATGATTATGACAAAATAGCTATCAATCAATTTGAAAAATTAT
TGTCTTATCTAAAGTTTATCACCAACCTTGATGTTTCTGAAAAAAATAAAGCACAAAGCGGAACCCTGAATTTTGATTTA
AATGCTATTCATTATAATGTGCGTGCTTCTACATTACCTCATTCGGTAGGTCATGAAGCATGTGTTTTAAGGATAATTCC
TACCAATTTTAATGAAAAAGCAGATATTGAAGATGATTTATTACATTTAATGCATAAAGGTAGTGGTCTGATTTTAATAA
GTGGACCAACGGGTAGTGGTAAGAGTACATTAATGTATCATCTGCTTCAATATGCAGTTGCAAATTTAAGTAAACAAGTG
ATATCGATAGAGGATCCTGTTGAACAAAGGATTGAAGGTATGATACAAATTAACGTCAACGCAAAAGGGAATATCACCTA
TCAGAATTCACTCAAAGCAATATTAAGATGTGATCCGGATATTATTATGATTGGCGAAATACGGGACGCAGATACCGCTA
AAAATGTAATCAATGCGAGTTTAAGTGGCCATCTAGTATTATCGACACTACATGCAAATTCCTGTTTAGGGGCAATACAT
CGATTGATGGAAATGGGCATCTCAAAAGTTGAACTTGAACAGAGTGTTGAAAGAATAATAAATCAAAGATTAGTAAACAC
TTGTTCTGGTAGAAGACGTGTTTACGAACAACTAAATAAGAGTGAATGTCGCAATTATTTATCTGATCAGTCATTAGATT
CATATCTCCCTATTAATAATCAATTAAATAAGATGCTTGATAATAATGAGATAACTTTAATGGAGCATGAACGTTATGTT
ACTGAGTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comGA | Staphylococcus aureus MW2 |
50.769 |
100 |
0.512 |
| comGA | Staphylococcus aureus N315 |
50.769 |
100 |
0.512 |