Detailed information NTG1091028

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACLZ8E_RS08395
• Genome accession: NZ_CP178726
• Coordinates: 1762113..1763159 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 13.4-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1757113..1768159

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLZ8E_RS08365 (ACLZ8E_08365)	-	1757497..1758738 (-)	1242	WP_001832467.1	aminopeptidase	-
ACLZ8E_RS08370 (ACLZ8E_08370)	-	1758740..1758955 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
ACLZ8E_RS08375 (ACLZ8E_08375)	-	1759096..1759560 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
ACLZ8E_RS08380 (ACLZ8E_08380)	-	1759568..1759852 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
ACLZ8E_RS08385 (ACLZ8E_08385)	-	1760259..1761437 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
ACLZ8E_RS08390 (ACLZ8E_08390)	vraR	1761494..1762123 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
ACLZ8E_RS08395 (ACLZ8E_08395)	vraS	1762113..1763159 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
ACLZ8E_RS08400 (ACLZ8E_08400)	liaF	1763156..1763857 (-)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
ACLZ8E_RS08405 (ACLZ8E_08405)	-	1763872..1764258 (-)	387	WP_001830382.1	hypothetical protein	-
ACLZ8E_RS08410 (ACLZ8E_08410)	map	1764416..1765171 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
ACLZ8E_RS08415 (ACLZ8E_08415)	-	1765345..1766331 (+)	987	WP_001830388.1	FUSC family protein	-
ACLZ8E_RS08420 (ACLZ8E_08420)	isaB	1766482..1767018 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=1091028 ACLZ8E_RS08395 WP_001830374.1 1762113..1763159(-) (vraS) [Staphylococcus epidermidis strain 13.4-1]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=1091028 ACLZ8E_RS08395 WP_001830374.1 1762113..1763159(-) (vraS) [Staphylococcus epidermidis strain 13.4-1]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92