Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   ACLZ8E_RS00285 Genome accession   NZ_CP178726
Coordinates   65463..67091 (-) Length   542 a.a.
NCBI ID   WP_001631035.1    Uniprot ID   -
Organism   Staphylococcus epidermidis strain 13.4-1     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 65463..106665 65463..67091 within 0


Gene organization within MGE regions


Location: 65463..106665
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLZ8E_RS00285 (ACLZ8E_00285) ccrB 65463..67091 (-) 1629 WP_001631035.1 cassette chromosome recombinase CcrB Machinery gene
  ACLZ8E_RS00290 (ACLZ8E_00290) ccrA 67088..68449 (-) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  ACLZ8E_RS00295 (ACLZ8E_00295) - 68636..69265 (-) 630 Protein_56 hypothetical protein -
  ACLZ8E_RS00300 (ACLZ8E_00300) - 69274..69612 (+) 339 Protein_57 recombinase family protein -
  ACLZ8E_RS00305 (ACLZ8E_00305) - 69724..70083 (-) 360 WP_001631039.1 hypothetical protein -
  ACLZ8E_RS00310 (ACLZ8E_00310) - 70290..70616 (+) 327 WP_000391495.1 ArsR/SmtB family transcription factor -
  ACLZ8E_RS00315 (ACLZ8E_00315) - 70946..72871 (+) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  ACLZ8E_RS00320 (ACLZ8E_00320) - 74097..75353 (+) 1257 WP_000566670.1 MrcB family domain-containing protein -
  ACLZ8E_RS00325 (ACLZ8E_00325) - 75768..76007 (+) 240 WP_001282728.1 hypothetical protein -
  ACLZ8E_RS00330 (ACLZ8E_00330) - 76039..76713 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  ACLZ8E_RS00335 (ACLZ8E_00335) - 76804..77787 (-) 984 Protein_64 protein rep -
  ACLZ8E_RS00340 (ACLZ8E_00340) mobV 78032..79294 (-) 1263 WP_000119405.1 MobV family relaxase -
  ACLZ8E_RS00345 (ACLZ8E_00345) bleO 79804..80208 (-) 405 WP_001242578.1 bleomycin binding protein -
  ACLZ8E_RS00350 (ACLZ8E_00350) - 80425..80895 (-) 471 Protein_67 kanamycin nucleotidyltransferase C-terminal domain-containing protein -
  ACLZ8E_RS00355 (ACLZ8E_00355) - 80942..81616 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  ACLZ8E_RS00360 (ACLZ8E_00360) - 81652..82041 (+) 390 WP_020444595.1 hydroxymethylglutaryl-CoA synthase -
  ACLZ8E_RS00365 (ACLZ8E_00365) - 82918..83661 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  ACLZ8E_RS00370 (ACLZ8E_00370) - 83758..84186 (+) 429 WP_000872606.1 MaoC family dehydratase -
  ACLZ8E_RS00375 (ACLZ8E_00375) mecA 84232..86241 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  ACLZ8E_RS00380 (ACLZ8E_00380) mecR1 86338..88095 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  ACLZ8E_RS00385 (ACLZ8E_00385) mecI 88095..88466 (+) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  ACLZ8E_RS00390 (ACLZ8E_00390) psm-mec 88551..88619 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  ACLZ8E_RS00395 (ACLZ8E_00395) - 88907..90048 (+) 1142 WP_089418807.1 IS3 family transposase -
  ACLZ8E_RS00400 (ACLZ8E_00400) - 90228..91358 (+) 1131 WP_010922808.1 ROK family transcriptional regulator -
  ACLZ8E_RS00405 (ACLZ8E_00405) cstB 91472..92806 (-) 1335 Protein_78 persulfide dioxygenase-sulfurtransferase CstB -
  ACLZ8E_RS00410 (ACLZ8E_00410) - 92839..93903 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  ACLZ8E_RS00415 (ACLZ8E_00415) cstR 94039..94299 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  ACLZ8E_RS00420 (ACLZ8E_00420) - 94299..94937 (+) 639 Protein_81 sulfite exporter TauE/SafE family protein -
  ACLZ8E_RS00425 (ACLZ8E_00425) - 95211..95827 (-) 617 Protein_82 CadD family cadmium resistance transporter -
  ACLZ8E_RS00430 (ACLZ8E_00430) - 95908..98322 (-) 2415 WP_000378485.1 cadmium-translocating P-type ATPase CadA -
  ACLZ8E_RS00435 (ACLZ8E_00435) - 98315..98680 (-) 366 WP_000159127.1 ArsR/SmtB family transcription factor -
  ACLZ8E_RS00440 (ACLZ8E_00440) - 98918..99295 (-) 378 WP_001041908.1 DUF6262 family protein -
  ACLZ8E_RS00445 (ACLZ8E_00445) - 99302..101194 (-) 1893 WP_002485298.1 site-specific integrase -
  ACLZ8E_RS00450 (ACLZ8E_00450) - 101389..101712 (-) 324 WP_000088091.1 JAB domain-containing protein -
  ACLZ8E_RS00455 (ACLZ8E_00455) - 101705..101911 (-) 207 WP_001077283.1 hypothetical protein -
  ACLZ8E_RS00460 (ACLZ8E_00460) - 101913..102434 (-) 522 WP_000836008.1 DUF1643 domain-containing protein -
  ACLZ8E_RS00465 (ACLZ8E_00465) - 102453..102764 (-) 312 WP_000833212.1 DUF960 family protein -
  ACLZ8E_RS00470 (ACLZ8E_00470) - 102849..103199 (-) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  ACLZ8E_RS00475 (ACLZ8E_00475) ccrB 103670..105298 (-) 1629 WP_001186596.1 cassette chromosome recombinase CcrB Machinery gene
  ACLZ8E_RS00480 (ACLZ8E_00480) ccrA 105319..106665 (-) 1347 WP_000816499.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62474.71 Da        Isoelectric Point: 9.6103

>NTDB_id=1091002 ACLZ8E_RS00285 WP_001631035.1 65463..67091(-) (ccrB) [Staphylococcus epidermidis strain 13.4-1]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=1091002 ACLZ8E_RS00285 WP_001631035.1 65463..67091(-) (ccrB) [Staphylococcus epidermidis strain 13.4-1]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA

Domains

Predicted by InterproScan.

Ogr/Delta-like zinc finger (Ogr_Delta)

(300-355)

Resolvase, N terminal domain (Resolvase)

(11-154)

Recombinase (Recombinase)

(179-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

72.694

100

0.727

Multiple sequence alignment