Detailed information NTG1089865

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACL211_RS04430
• Genome accession: NZ_CP178524
• Coordinates: 959460..960506 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain X15T2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 954460..965506

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACL211_RS04405	isaB	955602..956138 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
ACL211_RS04410	-	956288..957274 (-)	987	WP_002457091.1	FUSC family protein	-
ACL211_RS04415	map	957448..958203 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
ACL211_RS04420	-	958361..958747 (+)	387	WP_001830382.1	hypothetical protein	-
ACL211_RS04425	liaF	958762..959463 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
ACL211_RS04430	vraS	959460..960506 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
ACL211_RS04435	vraR	960496..961125 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
ACL211_RS04440	-	961182..962360 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
ACL211_RS04445	-	962767..963051 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
ACL211_RS04450	-	963059..963523 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
ACL211_RS04455	-	963664..963879 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
ACL211_RS04460	-	963881..965122 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=1089865 ACL211_RS04430 WP_001830374.1 959460..960506(+) (vraS) [Staphylococcus epidermidis strain X15T2]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=1089865 ACL211_RS04430 WP_001830374.1 959460..960506(+) (vraS) [Staphylococcus epidermidis strain X15T2]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92