Detailed information NTG0108529

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: C645_RS05250
• Genome accession: NZ_CP008740
• Coordinates: 1013113..1015683 (+)
• Length: 856 a.a.
• NCBI ID: WP_046067684.1
• Uniprot ID: -
• Organism: Haemophilus influenzae 2019
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1008113..1020683

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C645_RS05230 (C645_05305)	-	1008481..1008831 (-)	351	WP_046067682.1	hypothetical protein	-
C645_RS05235 (C645_05310)	polA	1008846..1011653 (-)	2808	WP_005655725.1	DNA polymerase I	-
C645_RS05240 (C645_05315)	-	1011802..1012104 (+)	303	WP_005655727.1	cell division protein ZapA	-
C645_RS05245 (C645_05320)	-	1012422..1012985 (+)	564	WP_046067683.1	5-formyltetrahydrofolate cyclo-ligase	-
C645_RS05250 (C645_05325)	clpC	1013113..1015683 (+)	2571	WP_046067684.1	ATP-dependent chaperone ClpB	Regulator
C645_RS05255 (C645_05330)	rlmB	1015720..1016460 (-)	741	WP_005655733.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
C645_RS05260 (C645_05335)	rnr	1016516..1018864 (-)	2349	WP_005655735.1	ribonuclease R	-
C645_RS05270 (C645_05345)	-	1019056..1019763 (-)	708	WP_005689123.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
C645_RS05275 (C645_05350)	pdxH	1019956..1020588 (+)	633	WP_005655740.1	pyridoxamine 5'-phosphate oxidase	-

Sequence

Protein

• Length: 856 a.a.
• Molecular weight: 95699.07 Da
• Isoelectric Point: 4.9553

>NTDB_id=108529 C645_RS05250 WP_046067684.1 1013113..1015683(+) (clpC) [Haemophilus influenzae 2019]
MNIEKFTTKFQEALSEAQSLAIGKDNQFIEPVHLLTALLNQQGGSIAPILTASGVNVALLRNELKTELNKLPQVIGNGGD
VQLSRQLINLLNLCDKFAQQNQDKFISSELFLFAALEERGTISDILKKCGAKKEQISQAIQHIRGGQNVNDQNAEESRQA
LEKYTIDLTARAESGKLDPVIGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSL
DMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVDEPSVEDTIAILRGLKERYEIHHHVDITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASS
IRMEIDSKPEPLDCLERRIIQLKLEQQALQKEEDEASRKRLEMLEKELAEKEREYAELEEVWKSEKATLSGSQHIKQELD
TAKTELEQARRAGDLAKMSELQYGRIPDLEKQLEQAETSEGKEMTLLRYRVTDEEIAEVLSKATGIPVSKMMEGEKEKLL
RMEDELHKRVIGQEEAVDAVANAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLAKFLFDSEDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHADVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQGNKDESYSEMKALVMSVVSQHFRPEFINRIDETVVFHPLGKENIRAIASIQLERLAKRMETRGYELVFTDALLD
FIGEVGYDPIYGARPLKRAIQQEIENSLAQQILSGALLPGKVVTIDYANAEVQARQ

Nucleotide

• Length: 2571 bp

>NTDB_id=108529 C645_RS05250 WP_046067684.1 1013113..1015683(+) (clpC) [Haemophilus influenzae 2019]
ATGAACATTGAAAAATTTACGACAAAATTCCAAGAAGCGTTAAGCGAAGCACAATCACTTGCTATCGGAAAAGACAATCA
ATTTATTGAACCCGTGCATTTATTGACCGCACTTTTAAATCAACAGGGCGGCTCTATTGCGCCAATTTTGACAGCAAGTG
GTGTAAATGTGGCGTTATTGCGTAATGAATTAAAGACAGAACTAAATAAATTGCCGCAAGTGATTGGCAATGGTGGAGAT
GTACAACTTTCACGCCAGCTTATTAATCTACTTAATTTATGCGATAAATTCGCACAGCAAAACCAAGATAAATTTATTTC
GAGCGAATTGTTTTTGTTTGCAGCTTTAGAAGAACGAGGAACGATCAGCGATATTTTGAAAAAGTGCGGTGCGAAAAAAG
AACAAATTTCGCAAGCTATTCAGCACATTAGAGGGGGACAAAACGTGAACGATCAAAATGCAGAAGAAAGCAGACAAGCG
CTTGAAAAATATACGATTGATTTAACCGCTCGTGCAGAAAGTGGCAAACTTGATCCTGTAATTGGGCGTGATGAAGAAAT
TCGTCGAGCCATTCAAGTATTACAACGTCGTACCAAAAATAACCCTGTGTTAATTGGTGAACCAGGTGTAGGGAAAACGG
CGATTGTCGAAGGCTTGGCACAGCGCATCGTAAACGGCGAAGTGCCAGAAGGTTTGAAAAATAAACGTGTGCTTTCATTA
GATATGGGGGCGTTGATTGCTGGTGCGAAATATCGTGGTGAATTTGAAGAACGTTTAAAAGCAGTACTCAATGAACTTTC
GAAAGAAGAAGGTCGCGTTATCCTCTTTATTGACGAAATTCATACTATGGTCGGCGCGGGTAAAACCGATGGTGCGATGG
ATGCGGGTAATTTGTTAAAACCAAGTTTGGCACGAGGCGAATTACATTGCGTGGGTGCAACTACTTTAGATGAATATCGT
CAATATATCGAAAAAGATGCCGCACTTGAACGCCGTTTCCAAAAAGTCTTTGTGGACGAACCAAGTGTAGAAGATACCAT
TGCGATCTTACGTGGTTTGAAAGAACGTTATGAAATTCATCATCACGTGGATATTACTGACCCAGCAATTGTCGCTGCAG
CAACGCTTTCACATCGTTATATTTCCGATCGTCAGTTACCAGATAAAGCCATTGATTTGATCGATGAAGCAGCGTCTAGC
ATTCGTATGGAAATAGATTCTAAACCTGAACCGCTTGATTGTCTTGAACGTCGTATTATCCAATTAAAATTGGAACAACA
AGCGTTACAAAAAGAAGAAGACGAAGCAAGTCGCAAACGTTTAGAAATGTTAGAGAAAGAATTGGCTGAAAAAGAACGTG
AATACGCCGAACTTGAAGAAGTATGGAAATCTGAAAAAGCAACGCTTTCTGGCTCTCAACATATTAAACAAGAGTTAGAT
ACTGCAAAAACCGAACTAGAACAAGCTCGTCGCGCGGGTGATTTAGCGAAAATGTCTGAGTTGCAATATGGCCGCATCCC
TGATCTTGAAAAGCAACTTGAGCAAGCTGAAACCAGCGAAGGAAAAGAAATGACGCTTTTACGCTATCGCGTCACAGATG
AAGAAATCGCAGAAGTGCTTTCTAAAGCCACAGGCATTCCTGTATCAAAAATGATGGAAGGCGAGAAAGAAAAACTCTTG
CGTATGGAAGATGAACTACATAAACGAGTGATTGGTCAAGAAGAAGCGGTTGATGCGGTAGCAAACGCGATTCGTCGTAG
TCGTGCAGGTCTTTCCGATCCTAATCGCCCAATTGGTTCTTTCTTGTTCCTAGGGCCAACAGGTGTTGGGAAAACAGAGC
TTTGCAAAACTTTGGCTAAATTCTTGTTTGATAGTGAAGATGCGATGGTGCGTATTGATATGTCAGAGTTTATGGAAAAA
CACAGTGTTTCTCGTTTAGTTGGTGCGCCTCCAGGCTATGTCGGCTATGAAGAAGGCGGTTATTTAACTGAAGCTGTTCG
TCGTCGTCCATATTCAGTGATCTTATTAGATGAAGTTGAAAAAGCACACGCAGATGTATTCAATATCTTATTACAAGTGT
TGGATGATGGTCGTTTAACTGATGGTCAAGGTCGTACTGTGGACTTCCGTAACACTGTGGTTATTATGACCTCTAACTTG
GGTTCTGATTTAATCCAAGGTAATAAAGACGAAAGCTATAGCGAAATGAAAGCCTTAGTGATGTCAGTGGTAAGCCAACA
TTTCCGCCCAGAATTCATCAACCGTATTGACGAAACCGTGGTATTCCATCCACTTGGTAAAGAAAATATCCGTGCGATTG
CAAGTATCCAATTAGAACGCTTAGCAAAACGTATGGAAACTCGTGGATACGAATTGGTGTTTACCGATGCTTTATTAGAC
TTCATTGGCGAAGTGGGATACGACCCAATTTATGGTGCACGTCCATTGAAACGTGCTATTCAACAAGAAATTGAAAACAG
CTTGGCACAACAAATTCTATCTGGTGCGTTATTACCTGGTAAGGTTGTTACCATTGATTATGCCAACGCAGAAGTTCAAG
CGAGACAATAG

Domains

Predicted by InterProScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (94-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA lid domain (AAA_lid_9) (342-443)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-758)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (765-845)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-336)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	46.843	100	0.477
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	43.572	100	0.447
clpE	Streptococcus pneumoniae TIGR4	48.899	79.556	0.389
clpE	Streptococcus pneumoniae R6	48.458	79.556	0.386
clpE	Streptococcus pneumoniae Rx1	48.458	79.556	0.386
clpE	Streptococcus pneumoniae D39	48.458	79.556	0.386
clpE	Streptococcus mutans UA159	47.724	79.556	0.38
clpC	Lactococcus lactis subsp. cremoris KW2	45.751	82.477	0.377