Detailed information NTG1082618

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACK2V1_RS04295
• Genome accession: NZ_CP176715
• Coordinates: 837183..838226 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GTVSS-007
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 832183..843226

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACK2V1_RS04265 (ACK2V1_04265)	-	832609..832719 (+)	111	WP_001790257.1	hypothetical protein	-
ACK2V1_RS04270 (ACK2V1_04270)	-	832748..833161 (+)	414	WP_001557448.1	hypothetical protein	-
ACK2V1_RS04275 (ACK2V1_04275)	-	833592..834578 (-)	987	WP_000999717.1	FUSC family protein	-
ACK2V1_RS04280 (ACK2V1_04280)	map	835109..835867 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACK2V1_RS04285 (ACK2V1_04285)	-	836084..836470 (+)	387	WP_001110179.1	hypothetical protein	-
ACK2V1_RS04290 (ACK2V1_04290)	liaF	836485..837186 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACK2V1_RS04295 (ACK2V1_04295)	vraS	837183..838226 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACK2V1_RS04300 (ACK2V1_04300)	vraR	838216..838845 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
ACK2V1_RS04305 (ACK2V1_04305)	-	838958..840175 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
ACK2V1_RS04310 (ACK2V1_04310)	-	840453..840728 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ACK2V1_RS04315 (ACK2V1_04315)	-	840735..841199 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACK2V1_RS04320 (ACK2V1_04320)	-	841346..841546 (+)	201	WP_000180460.1	DUF1128 family protein	-
ACK2V1_RS04325 (ACK2V1_04325)	-	841549..842805 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1082618 ACK2V1_RS04295 WP_001017131.1 837183..838226(+) (vraS) [Staphylococcus aureus strain GTVSS-007]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1082618 ACK2V1_RS04295 WP_001017131.1 837183..838226(+) (vraS) [Staphylococcus aureus strain GTVSS-007]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1