Detailed information NTG1080960

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ACKZ7V_RS12845
• Genome accession: NZ_CP176566
• Coordinates: 2590012..2591055 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IMT37083
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2585012..2596055

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACKZ7V_RS12815 (ACKZ7V_12815)	-	2585433..2586689 (-)	1257	WP_078064589.1	aminopeptidase	-
ACKZ7V_RS12820 (ACKZ7V_12820)	-	2586692..2586892 (-)	201	WP_000180460.1	DUF1128 family protein	-
ACKZ7V_RS12825 (ACKZ7V_12825)	-	2587039..2587503 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
ACKZ7V_RS12830 (ACKZ7V_12830)	-	2587510..2587785 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
ACKZ7V_RS12835 (ACKZ7V_12835)	-	2588063..2589280 (+)	1218	WP_148843683.1	YihY/virulence factor BrkB family protein	-
ACKZ7V_RS12840 (ACKZ7V_12840)	vraR	2589393..2590022 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
ACKZ7V_RS12845 (ACKZ7V_12845)	vraS	2590012..2591055 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ACKZ7V_RS12850 (ACKZ7V_12850)	liaF	2591052..2591753 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ACKZ7V_RS12855 (ACKZ7V_12855)	-	2591768..2592154 (-)	387	WP_001110179.1	hypothetical protein	-
ACKZ7V_RS12860 (ACKZ7V_12860)	map	2592370..2593128 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ACKZ7V_RS12865 (ACKZ7V_12865)	-	2593598..2594584 (+)	987	WP_111762469.1	FUSC family protein	-
ACKZ7V_RS12870 (ACKZ7V_12870)	-	2594957..2595370 (-)	414	WP_111762822.1	hypothetical protein	-
ACKZ7V_RS12875 (ACKZ7V_12875)	-	2595399..2595509 (-)	111	WP_111762470.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1080960 ACKZ7V_RS12845 WP_001017131.1 2590012..2591055(-) (vraS) [Staphylococcus aureus strain IMT37083]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1080960 ACKZ7V_RS12845 WP_001017131.1 2590012..2591055(-) (vraS) [Staphylococcus aureus strain IMT37083]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTGGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1