Detailed information NTG0107797

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AACH49_RS04580
• Genome accession: NZ_AP028991
• Coordinates: 950650..951693 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TUM19381
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 945650..956693

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AACH49_RS04550	-	946078..946188 (+)	111	WP_001790257.1	hypothetical protein	-
AACH49_RS04555 (TUM19381_08620)	-	946217..946630 (+)	414	WP_001670387.1	hypothetical protein	-
AACH49_RS04560 (TUM19381_08630)	-	947061..948047 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
AACH49_RS04565 (TUM19381_08640)	map	948576..949334 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AACH49_RS04570 (TUM19381_08650)	-	949551..949937 (+)	387	WP_001110179.1	hypothetical protein	-
AACH49_RS04575 (TUM19381_08660)	liaF	949952..950653 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AACH49_RS04580 (TUM19381_08670)	vraS	950650..951693 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AACH49_RS04585 (TUM19381_08680)	vraR	951683..952312 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AACH49_RS04590 (TUM19381_08690)	-	952425..953642 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
AACH49_RS04595 (TUM19381_08700)	-	953920..954195 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
AACH49_RS04600 (TUM19381_08710)	-	954202..954666 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AACH49_RS04605 (TUM19381_08720)	-	954813..955013 (+)	201	WP_000180460.1	DUF1128 family protein	-
AACH49_RS04610 (TUM19381_08730)	-	955016..956272 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=107797 AACH49_RS04580 WP_001017131.1 950650..951693(+) (vraS) [Staphylococcus aureus strain TUM19381]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=107797 AACH49_RS04580 WP_001017131.1 950650..951693(+) (vraS) [Staphylococcus aureus strain TUM19381]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1