Detailed information NTG1076078

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: ACJEH2_RS01470
• Genome accession: NZ_CP174235
• Coordinates: 336637..339369 (+)
• Length: 910 a.a.
• NCBI ID: WP_011215874.1
• Uniprot ID: Q5WVD9
• Organism: Legionella pneumophila strain SPF590
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 331637..344369

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACJEH2_RS01450 (ACJEH2_01450)	gstA	331783..332388 (-)	606	WP_011215870.1	glutathione transferase GstA	-
ACJEH2_RS01455 (ACJEH2_01455)	-	332585..333580 (-)	996	WP_011215871.1	hypothetical protein	-
ACJEH2_RS01460 (ACJEH2_01460)	-	333621..334883 (-)	1263	WP_011215872.1	serine hydrolase	-
ACJEH2_RS01465 (ACJEH2_01465)	gltX	335126..336538 (-)	1413	WP_011215873.1	glutamate--tRNA ligase	-
ACJEH2_RS01470 (ACJEH2_01470)	letS	336637..339369 (+)	2733	WP_011215874.1	two-component system sensor histidine kinase LetS	Regulator
ACJEH2_RS01475 (ACJEH2_01475)	-	339467..340711 (+)	1245	WP_011215875.1	6-phosphofructokinase	-
ACJEH2_RS01480 (ACJEH2_01480)	pilA2	340708..341121 (-)	414	WP_011215876.1	pilin	Machinery gene
ACJEH2_RS01485 (ACJEH2_01485)	pilA2	341319..341732 (-)	414	WP_011215877.1	pilin	Machinery gene
ACJEH2_RS01490 (ACJEH2_01490)	-	342034..342351 (+)	318	WP_011215878.1	BolA family transcriptional regulator	-
ACJEH2_RS01495 (ACJEH2_01495)	-	342426..343847 (+)	1422	WP_011215879.1	APC family permease	-

Sequence

Protein

• Length: 910 a.a.
• Molecular weight: 102912.46 Da
• Isoelectric Point: 7.7914

>NTDB_id=1076078 ACJEH2_RS01470 WP_011215874.1 336637..339369(+) (letS) [Legionella pneumophila strain SPF590]
MLKSIGIKYQLRITTLIPAFLVALLFAFFYNGLFGKDLKQHMSRLGEAYIRQLLPAAQYAMLRNDYRTLQGLINASTINP
EVKALAFYNADGRLIAYRGGKHSIHKPFNPPDYTGDYIESKQINPFTINFIAPITIPKFNLYSSTEFKEPSTPKIFQADD
ILGWLSIDIDTQSLLIKRYQMLIVTIFITLFGLLMGLTIHYFLSKRIYMPIARLRRSMKQILSNEFETEIRVSSPGELGI
IEKGCAHLQRQYLNTVRDLNHHIEIATADLQQSLELLEEKNIELSLEKKKTEEKSRQKSEFIANMSHEIRTPMNGVIGFT
NVLLESKLDPLQLDYVKTIKSSAQDLLSIINAILDFSKIDAGKLNLDCIPLDVRGCIDEVLSLASPNAHKKVIDLIPITD
INVPKMVLGDPLRIKQIISNLVTNAVKFTDHGYVLIRTKIEQETDKDYTLLFAITDTGIGISPEDQTKLFTAFNQADTSI
TRRYGGSGLGLVICKKLCEEMHGRISLTSEINKGSTFSARIKVEKLVAYEIEKNQTHRFAHLKIICFDDNPLHLEAIGNG
LGFWGIEAIRVDSFNKLSRTLTKHKDCKIAFINVNQGCERQAAELIAKHKQIPFVLISKWPINDFAALGARGFLYKPISI
QKLQDLIESIANENQTEKNTNQELDTLREQLRFLHPEILIAEDNPVNKMLLTSLLNNNANITTVDDGEMAVTACEDKKFD
MILLDLHMPKLNGLEAAKMIRQKSLMNKHSPIVLITASSSDLSSIDMKKSGVDFCFQKPIDEKQLLIQILRIVDKIKHAA
IDWQLCVQKVSGNQALAEEFLAKFIEELYKNREEFIGLMHQKNVKGLADLAHKLHGACCFCGVPILQKRVAQLEKLARRT
ANADNLSEAFTDLIQSIDAVISEYENQYSQ

Nucleotide

• Length: 2733 bp

>NTDB_id=1076078 ACJEH2_RS01470 WP_011215874.1 336637..339369(+) (letS) [Legionella pneumophila strain SPF590]
ATGTTGAAAAGTATTGGTATTAAATATCAGCTAAGAATCACTACTCTTATTCCTGCCTTTTTAGTCGCCTTGCTTTTTGC
TTTTTTTTATAACGGCCTATTTGGTAAAGATCTAAAGCAGCATATGTCCAGACTGGGTGAAGCCTATATCAGGCAATTAC
TTCCAGCAGCCCAGTATGCCATGCTTCGCAATGATTACCGTACATTGCAGGGTTTAATCAATGCCTCAACCATTAACCCG
GAGGTAAAAGCTTTGGCATTTTATAATGCCGATGGCCGATTAATTGCTTATCGTGGCGGCAAGCACTCTATCCATAAACC
ATTCAATCCACCTGACTATACAGGTGACTACATTGAAAGTAAGCAAATTAATCCATTCACCATTAATTTTATAGCGCCGA
TTACTATCCCAAAGTTCAATTTGTACTCAAGCACAGAATTCAAAGAGCCTTCTACGCCTAAAATATTCCAGGCTGACGAT
ATATTAGGCTGGTTATCCATTGACATTGATACACAATCACTACTTATAAAACGCTATCAAATGCTCATCGTTACCATTTT
TATTACTCTATTCGGTTTACTGATGGGTTTAACAATTCATTACTTCTTGTCTAAACGAATTTACATGCCTATTGCTCGAT
TGCGTCGAAGTATGAAGCAAATTTTAAGCAATGAATTTGAAACTGAAATTCGTGTTTCAAGTCCAGGAGAATTAGGAATA
ATTGAAAAAGGTTGCGCTCATTTACAACGACAATATTTAAATACAGTTCGTGATTTGAATCATCACATTGAAATCGCCAC
AGCAGATCTGCAACAAAGTCTCGAACTTCTGGAAGAAAAAAACATTGAGCTATCACTGGAAAAGAAAAAAACTGAAGAAA
AAAGTCGACAAAAATCAGAATTTATTGCCAACATGAGTCATGAAATTCGCACCCCAATGAATGGCGTGATTGGTTTTACA
AATGTTTTATTGGAAAGCAAGCTGGACCCTTTACAACTGGACTACGTTAAAACGATCAAATCATCAGCGCAGGATTTGTT
AAGTATCATCAATGCTATTCTGGATTTTTCTAAAATTGATGCGGGCAAATTAAATCTTGATTGCATCCCGCTAGACGTAA
GAGGTTGCATTGATGAGGTTTTATCCCTGGCAAGCCCCAATGCGCACAAAAAAGTAATCGATTTAATCCCGATTACAGAC
ATCAATGTGCCCAAAATGGTATTGGGTGACCCTTTAAGAATCAAACAAATCATCAGTAATCTGGTGACCAATGCAGTAAA
ATTTACAGATCATGGATACGTTCTTATACGCACTAAAATCGAGCAAGAAACAGATAAAGATTATACCTTACTATTTGCTA
TTACGGATACGGGAATAGGTATTTCACCAGAGGATCAAACGAAACTGTTTACTGCCTTCAATCAGGCAGACACCAGCATC
ACACGCCGTTACGGTGGCTCAGGATTAGGCTTGGTTATATGTAAAAAACTATGTGAAGAAATGCATGGACGTATTAGTCT
AACCAGTGAAATCAACAAAGGCTCTACTTTTAGCGCACGCATTAAAGTTGAAAAACTTGTGGCTTATGAGATTGAAAAAA
ATCAAACTCATCGTTTCGCCCATTTAAAAATCATTTGCTTTGATGACAATCCCCTCCATTTGGAAGCAATAGGTAATGGC
TTGGGATTTTGGGGTATAGAGGCTATACGCGTTGACTCATTTAATAAACTTTCCCGAACATTGACAAAACATAAAGATTG
TAAAATTGCCTTTATTAACGTCAACCAAGGATGTGAGCGACAAGCTGCTGAACTCATTGCCAAACACAAGCAAATTCCTT
TCGTGTTAATTTCTAAATGGCCTATTAATGATTTTGCGGCGCTTGGTGCTCGGGGTTTTCTTTACAAACCTATCAGCATC
CAAAAGCTTCAGGATCTGATTGAATCGATAGCCAATGAAAACCAAACTGAGAAAAATACGAACCAGGAACTGGATACTTT
ACGCGAACAGCTTCGTTTTCTTCATCCAGAGATACTGATTGCAGAAGACAACCCTGTCAATAAAATGCTATTAACATCCC
TATTAAACAATAATGCCAATATAACCACGGTTGACGATGGCGAAATGGCCGTTACTGCTTGTGAGGATAAAAAATTTGAC
ATGATTTTACTGGATCTGCATATGCCCAAACTTAATGGTTTGGAAGCAGCCAAAATGATACGTCAAAAATCCCTAATGAA
TAAACACTCTCCTATCGTTCTCATTACCGCCAGTAGCAGTGATCTGAGTTCTATCGATATGAAAAAATCTGGAGTTGATT
TTTGTTTTCAAAAACCTATAGATGAAAAGCAATTGTTAATCCAAATTCTTCGCATCGTTGATAAAATCAAACATGCTGCC
ATTGATTGGCAATTATGCGTTCAGAAAGTTTCAGGTAATCAAGCGCTTGCTGAAGAGTTCCTCGCCAAATTTATAGAAGA
ATTATATAAGAATCGTGAAGAGTTTATTGGGTTAATGCATCAAAAAAACGTAAAGGGCCTGGCTGATTTGGCTCATAAAT
TACATGGCGCCTGTTGTTTTTGTGGCGTGCCTATTTTACAAAAGAGAGTAGCTCAATTAGAGAAGCTTGCAAGACGAACA
GCTAATGCTGATAATTTAAGCGAAGCCTTTACCGATTTAATACAAAGTATTGATGCGGTGATTAGTGAATATGAAAATCA
GTACTCACAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (678-787)

• His Kinase A (phospho-acceptor) domain (HisKA) (298-362)

• Hpt domain (Hpt) (819-900)

• Single cache domain 4 (sCache_4) (36-180)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (409-524)

3D structure

• AlphaFold DB: Q5WVD9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	99.011	100	0.99