Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   ACAM22_RS06335 Genome accession   NZ_AP028929
Coordinates   1395852..1398110 (+) Length   752 a.a.
NCBI ID   WP_369606523.1    Uniprot ID   A0AAT9G1R2
Organism   Streptococcus sp. SN-1     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1390852..1403110
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACAM22_RS06305 (MASAN616_12390) - 1390920..1391774 (-) 855 WP_261050317.1 NAD(P)H-hydrate dehydratase -
  ACAM22_RS06310 (MASAN616_12400) - 1391789..1392610 (-) 822 WP_261050320.1 phosphate ABC transporter ATPase -
  ACAM22_RS06315 (MASAN616_12410) - 1392747..1393604 (-) 858 WP_369606521.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  ACAM22_RS06320 (MASAN616_12420) - 1393782..1394516 (-) 735 WP_369606522.1 amino acid ABC transporter ATP-binding protein -
  ACAM22_RS06325 (MASAN616_12430) - 1394516..1395199 (-) 684 WP_001011642.1 amino acid ABC transporter permease -
  ACAM22_RS06330 (MASAN616_12440) - 1395391..1395621 (+) 231 WP_000443570.1 DUF1797 family protein -
  ACAM22_RS06335 (MASAN616_12450) clpE 1395852..1398110 (+) 2259 WP_369606523.1 AAA family ATPase Regulator
  ACAM22_RS06340 (MASAN616_12460) - 1398240..1398692 (+) 453 WP_153196233.1 NUDIX hydrolase -
  ACAM22_RS06345 (MASAN616_12470) - 1398751..1399050 (+) 300 WP_369606524.1 DUF1827 family protein -
  ACAM22_RS06350 (MASAN616_12480) ezrA 1399228..1400955 (-) 1728 WP_369606525.1 septation ring formation regulator EzrA -
  ACAM22_RS06355 (MASAN616_12490) gyrB 1401037..1402983 (-) 1947 WP_000134041.1 DNA topoisomerase (ATP-hydrolyzing) subunit B -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83833.36 Da        Isoelectric Point: 5.2972

>NTDB_id=107336 ACAM22_RS06335 WP_369606523.1 1395852..1398110(+) (clpE) [Streptococcus sp. SN-1]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNHFRPSNNTPPTPP
TQSGGGYGGNGGYGSQNRGPAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETIIILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLILNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKVTDQDTPIISEKTIEYIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKTSEKEV

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=107336 ACAM22_RS06335 WP_369606523.1 1395852..1398110(+) (clpE) [Streptococcus sp. SN-1]
ATGCTTTGTCAAAACTGTAAAATCAACGACTCAACAATTCATCTTTATACCAATCTCAATGGAAAACAAAAGCAAATTGA
CCTCTGTCAAAACTGCTACAAGATTATCAAAACAGATCCTAACAATAGCCTCTTTAAAGGTATGACAGATTTGAATAATC
GTGACTTTGATCCTTTTGGTGATTTCTTCAATGACTTAAACCATTTTAGACCTTCTAACAACACTCCTCCTACTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGTAACGGCGGTTATGGTTCCCAAAATCGTGGACCTGCTCAAACTCCACCACCAAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAGATTGCTCGTCGTGGCGATATCGACCCCGTTATTG
GACGAGATGATGAGATTATCCGTGTCATCGAAATTCTCAATCGTAGAACTAAGAATAATCCTGTTCTTATCGGTGAACCA
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAAAAAATCGTTGATGGCGATGTTCCCCATAAACTCCAAGGTAA
ACAAGTTATCCGTCTGGATGTGGTTAGCCTGGTTCAAGGAACAGGTATCCGAGGACAATTTGAAGAACGCATGCAAAAGC
TCATGGAAGAAATTCGCAAACGTGAGGATATTATCCTCTTTATCGATGAAATCCATGAAATTGTCGGTGCAGGTTCTGCA
GGCGATGGCAATATGGATGCTGGAAATATCCTCAAGCCCGCCCTTGCTCGTGGCGAACTGCAACTGGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTAGAACGTCGTATGCAGCCTGTTAAGGTTGATGAACCAACGG
TAGAGGAAACGATTATTATCCTCAAAGGAATTCAAAAGAAATACGAAGACTACCACCACGTTCAATATACCGATGCTGCA
ATTGAAGCAGCAGCAACTCTTTCCAATCGTTACATCCAAGATCGCTTCTTACCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAATTTGATCTTGAATTTTGTCGATCCTAAAGTCATTGATCAACGCTTGATTGAGGCTGAAAATC
TCAAATCTCAAGCTACACGGGAGGAAGATTTTGAGAAGGCCGCCTATTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGGTCACAGACCAGGATACTCCTATCATCAGCGAGAAAACCATTGAGTACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTAAAAGAGAAAGAACAATCTCAACTCATCCATTTAGCCGAAGATCTTAAGTCTCATGTTATTG
GTCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTTGGACTTGGTACGCCTAACCGTCCAATT
GGAAGCTTCCTCTTTGTCGGGCCAACGGGTGTCGGTAAGACAGAACTTTCCAAACAACTAGCTATCGAACTTTTTGGTTC
TGCTGATAGCATGATTCGCTTTGATATGAGTGAATATATGGAGAAACACAGCGTGGCTAAGTTGGTCGGTGCCCCTCCAG
GTTATGTTGGCTATGACGAGGCTGGTCAGTTAACGGAAAAAGTTCGCCGCAATCCATATTCTCTCATCCTTCTCGATGAA
GTAGAAAAAGCTCACCCTGATGTTATGCACATGTTCCTTCAAGTCTTGGACGATGGCCGTTTAACGGATGGTCAAGGTCG
AACTGTTAGCTTTAAGGACGCCATCATTATCATGACCTCAAATGCAGGTACAGGTAAGGCTGAAGCAAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGGACAAACTCCGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAGGACAACCTCCTTCAGATTGTCGAGCTTATGCTAGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATTCATTTAGATGTAACAGACAAGGTCAAGGAAAAATTAGTTGACCTCGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGCCGCACTATTCAAGACTATATTGAAGACGCAATCACTGACTACTACCTTGAAAATCCA
AGTGAAAAAGATCTCAAGGCAGTTATGACCAGCAAGGGAAACATTCAAATTAAGTCTGCCAAAAAAGCTGAAGTTAAAAC
TTCTGAAAAAGAAGTATAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

AAA lid domain (AAA_lid_9)

(293-390)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

98.003

99.867

0.979
  clpE Streptococcus pneumoniae D39

98.003

99.867

0.979
  clpE Streptococcus pneumoniae R6

98.003

99.867

0.979
  clpE Streptococcus pneumoniae TIGR4

97.87

99.867

0.977
  clpE Streptococcus mutans UA159

82.933

99.734

0.827
  clpC Lactococcus lactis subsp. cremoris KW2

75.099

100

0.758
  clpC Bacillus subtilis subsp. subtilis str. 168

52.308

86.436

0.452
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.847

83.378

0.399
  clpC Streptococcus pneumoniae Rx1

46.751

83.91

0.392
  clpC Streptococcus pneumoniae D39

46.751

83.91

0.392
  clpC Streptococcus pneumoniae TIGR4

46.751

83.91

0.392
  clpC Streptococcus mutans UA159

46.89

83.378

0.391
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386

Multiple sequence alignment