Detailed information NTG1070769

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: ACIVIR_RS00360
• Genome accession: NZ_CP173225
• Coordinates: 57218..58255 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 262
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 52218..63255

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACIVIR_RS00335	-	52957..54288 (-)	1332	WP_000390039.1	hemolysin family protein	-
ACIVIR_RS00340	endA	54579..55403 (-)	825	WP_001036791.1	DNA-entry nuclease EndA	Machinery gene
ACIVIR_RS00345	-	55442..55630 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
ACIVIR_RS00350	murA	55623..56906 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
ACIVIR_RS00355	-	56930..57160 (-)	231	WP_000250393.1	DUF1146 family protein	-
ACIVIR_RS00360	sepM	57218..58255 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
ACIVIR_RS00365	coaD	58239..58727 (-)	489	WP_050221168.1	pantetheine-phosphate adenylyltransferase	-
ACIVIR_RS00370	rsmD	58717..59256 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
ACIVIR_RS00375	asnA	59321..60313 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
ACIVIR_RS00380	-	60425..61108 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
ACIVIR_RS00385	-	61164..61904 (-)	741	WP_000152692.1	RNA methyltransferase	-
ACIVIR_RS00390	-	61938..62216 (+)	279	WP_001174613.1	acylphosphatase	-
ACIVIR_RS00395	yidC	62294..63220 (+)	927	WP_000835949.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=1070769 ACIVIR_RS00360 WP_000727277.1 57218..58255(-) (sepM) [Streptococcus pneumoniae strain 262]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=1070769 ACIVIR_RS00360 WP_000727277.1 57218..58255(-) (sepM) [Streptococcus pneumoniae strain 262]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAATTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591